The effects of aqueous extracts of Lippia citriodora , Trachyspermum copticum , Dracocepalum polychaetum on repair of ethanol induced gastric ulcer in rats

Abstract To evaluate the effects of Lippia citriodora, Trachyspermum copticum, and Dracocepalum polychaetum on healing of gastric ulcer induced by ethanol, 25 male Sprague–Dawley rats were divided into five groups (five rats in each group). After 24-h starvation, all animals received oral ethanol (1 mL/200 g body weight). Three groups received 2 mL (100 mg/kg/day) of L. citriodora (LC group), D. polychaetum (DP group), and T. copticum (TC group) aqueous extracts; one group (RA) received ranitidine (200 mg/kg/day); and one group (control) received 2 mL distilled water saline by gastric gavage for four consecutive days. On the fourth day, macroscopic evaluation of gastric mucosa revealed significantly higher healing rate in DP and TC groups than in control group (p = 0.048 and p = 0.044, respectively). The ulcer severity in LC and TC groups was also significantly less than in control group (p = 0.018 and p = 0.005, respectively). The lower gastric ulcer score in DP group in comparison with control group was also marginally significant (p = 0.08). Histopathologic evaluation showed sloughing of gastric mucosa and various sizes of erosions and ulcers besides hyperemia, hemorrhage, and infiltration of inflammatory cells in control group. The highest curative effect was observed in TC group, in which the gastric mucosa obtained almost normal thickness and there were onl...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Conclusion: We presented a rare case of BD with the concurrence of huge esophageal ulcer and thoracic aortic aneurysms rupture, which helped us to diagnose BD at the early stage, while confronting atypical manifestations.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: The expression of lncRNAs is abnormal in the kidney of LN. LncRNA RP11-2B6.2 is a novel positive regulator of IFN-I pathway through epigenetic inhibition of SOCS1, which provides a new therapeutic target to alleviate over-activated IFN-I signaling in LN. Introduction Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by the occurrence of a wide range of autoantibodies and organ damage and predominantly affects women at childbearing age (1, 2). Lupus nephritis (LN) is considered one of the most prevalent and serious complications of SLE with high morbidity and mortali...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThese results together with the literature data reinforce the anti-hypersensitivity and anti-inflammatory activity of A. moluccanus extract. Part of the observed effects is due to the presence of the compound 2″-O-rhamnosylswertisin. The fact that the extract acted as a disease modifier point this herbal product as a promisor and safe tool to treat RA and other associated chronic diseases.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThese results together with the literature data reinforce the anti-hypersensitivity and anti-inflammatory activity of A. moluccanus extract. Part of the observed effects is due to the presence of the compound 2”-O-rhamnosylswertisin. The fact that the extract acted as a disease modifier point this herbal product as a promisor and safe tool to treat RA and other associated chronic diseases.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionCameron ulcer is a rare cause of iron deficiency anemia from chronic blood loss. It is fatal but easily treatable ulcer at hiatal hernia. It very rare in pediatrics age particularly under five children and high index of suspicion is lifesaving.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
A 57-year-old woman with a history of multiple ventral hernia mesh repairs, with the most recent hernia repair 2 years ago, and a nonhealing gastric ulcer for the past 8 months (Figure A, white arrow) presented with acute onset of abdominal pain, nausea, vomiting, swelling, and redness in the midabdomen for the past 3 days. A computed tomography scan of the abdomen showed prior ventral abdominal wall hernia mesh repair with development of an abscess within the subcutaneous tissues of the anterior abdominal wall (Figure B, red arrow)  in addition to a possible intra-abdominal fistulous communication where the stomach a...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Electronic Image of the Month Source Type: research
ConclusionA SLT approach is a suitable minimally invasive option for the surgical management of hemostasis and closure of bleeding gastric ulcers not amenable to endoscopic or radiological interventions.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
In conclusion, the secretome from hypoxia-conditioned ADMSCs facilitates the repair of gastric mucosal injury through the enhancement of angiogenesis and re-epithelization, as well as the activation of COX2-PGE2 axis with a paracrine activity involving CCL-20 factor.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
In conclusion, the secretome from hypoxia-conditioned ADMSCs facilitates the repair of gastric mucosal injury through the enhancement of angiogenesis and re-epithelization, as well as the activation of COX2-PGE2 axis with a paracrine activity involving CCL-20 factor. PMID: 28993190 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research
Authors: Yoo IK, Chun HJ, Jeen YT Abstract Intragastric balloon (IGB) insertion has been most frequently used in the West as an effective endoscopic treatment for morbid obesity, in practice. Recently, there is a growing number of cases requiring IGB deployment for obesity treatment in Korea. One of the reported complications of IGB use is gastric perforation. A 47-year-old woman was admitted to the hospital with mild symptoms, 7 weeks after having an IGB placed. Esophagogastroduodenoscopy was performed and gastric ulcer perforation was observed in the ulcer base, where food particles were impacted. Laparoscopic pr...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
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