Non-coding RNAs in cardiovascular ageing.

Non-coding RNAs in cardiovascular ageing. Ageing Res Rev. 2014 Jan 31; Authors: Gupta SK, Piccoli MT, Thum T Abstract The increasing burden of ageing populations and their healthcare expenditure is a major challenge worldwide. Ageing is a complex disorder and can be defined as progressive decline in function with time leading to increased incidence of various cardiovascular, neurological and immunological diseases. The human genome comprises of many protein coding and even more non-coding RNA genes. MicroRNAs, a class of non-coding RNA, regulate the expression of multiple messenger RNAs post-transcriptionally and are reported to be involved in crucial aspects of cell biology encompassing ageing. Recently, several studies have reported the regulation of microRNAs with ageing and microRNAs like miR-34 have emerged as critical regulator of ageing extending from C. elegans to mammals. Here, we summarize the reported role of microRNAs as well as long-non coding RNAs (lncRNAs) in the process of ageing with a special emphasis on cardiovascular ageing. PMID: 24491506 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research