Autoimmune Reactivity in Graft Injury: Player or Bystander?

Abstract Organ transplantation is the only viable treatment for several end-stage organ failures. However, chronic rejection prevents long-term graft survival. Traditionally, this rejection was attributed to the development of alloimmunity in transplant patients. However, recent evidence suggests that autoimmunity plays a larger role in chronic rejection of certain organ transplants, than alloimmunity. In this review, we will focus on the history of autoimmunity in solid organ transplantation and look at the collagen type V, Kα1 tubulin, vimentin, cardiac myosin, and heat shock proteins as classical examples of autoantigens in organ transplantation. We will also look at some of the recent reports looking at the mechanisms of autoimmunity and try to provide answers to some of the age-old questions in autoimmunity.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

Related Links:

Publication date: Available online 23 August 2019Source: American Journal of Kidney DiseasesAuthor(s): Olivier Niel, Paul BastardArtificial intelligence is playing an increasingly important role in many fields of medicine, assisting physicians in most steps of patient management. In nephrology, artificial intelligence can already be used to improve clinical care, hemodialysis prescriptions, and follow-up of transplant recipients. However, many nephrologists are still unfamiliar with the basic principles of medical artificial intelligence. This review seeks to provide an overview of medical artificial intelligence relevant ...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionThese clinical practice recommendations should guide and improve the daily practice of gastro-intestinal surgeons.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionRapid and accurate diagnosis of A-AIH may be difficult. However, timely start of immunosuppressive therapy improves prognosis and decreases number of indicated liver transplantations in children with AIH.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
We report a rare case of a primary intraventricular CNS classical HL-PTLD in a male patient, 18 years following renal transplantation. The location allowed for safe neurosurgical intervention which resolved the symptom of elevated intracranial pressure and allowed for induction of a Rituximab-based chemotherapy regimen. Both the ventricular location of the PTLD and Hodgkin Lymphoma PTLD are themselves individually quite rare and have not previously been reported together. The unique location allowed safe neurosurgical intervention which quickly resolved the symptom of elevated intracranial pressure and allowed for induct...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 24 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): Gita N. Mody, Hari R. MallidiAbstractDissemination of surgical techniques to manage rare donor airway anomalies may improve outcomes after lung transplantation. Here we report a case of an unsuspected donor tracheal bronchus that was successfully managed with a native right mainstem bronchoplasty.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSION: The splenic artery has quite different variation types and knowledge of these variations are useful for the planning and conduct of surgical and radiological procedures of the upper abdomen, including laparoscopic operations. Our study is the first in the medical literature classifying variations in the origin and branching pattern of the splenic artery. PMID: 31436304 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
CONCLUSION: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis. PMID: 31435074 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Lung transplantation is an established therapeutic option for patients with irreversible end-stage pulmonary disease limiting life expectancy and quality of life. Common indications for lung transplantation include chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, and alpha-1 antitrypsin deficiency. Complications of lung transplantation can be broadly divided etiologically into surgical, infectious, immunologic, or neoplastic. Moreover, specific complications often occur within a certain time interval following surgery, which can be broadly classified as...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Review Articles Source Type: research
ConclusionsIn recipients concurrently listed for SLT and DLT, overall survival was similar regardless of the eventual procedure. These data suggests that the previously purported survival advantage for DLT may purely represent selection bias, and should not preclude the use of SLT in appropriately-selected IPF patients.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 22 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): Hiromi Oda, Masatsugu Hamaji, Hideki Motoyama, Tadashi Ikeda, Kenji Minatoya, Daisuke Nakajima, Toyofumi Fengshi Chen-Yoshikawa, Hiroshi DateAbstractManagement of a giant pulmonary trunk aneurysm in lung transplantation is a challenge. Herein, we present a patient undergoing replacement of the giant pulmonary artery (PA) aneurysm with a donor’s aorta in bilateral lung transplantation for idiopathic pulmonary arterial hypertension (IPAH). A plastic three-dimensional (3D) model of the PA aneurysm created accurately based o...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
More News: Transplant Surgery | Transplants