Mozart's music in children with drug-refractory epileptic encephalopathies
Publication date: September 2015 Source:Epilepsy & Behavior, Volume 50 Author(s): Giangennaro Coppola , Annacarmela Toro , Francesca Felicia Operto , Giuseppe Ferrarioli , Simone Pisano , Andrea Viggiano , Alberto Verrotti Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG discharges and recurrence of clinical seizures in both adults and young patients. In this prospective, open-label study, we evaluated the effect of listening to a set of Mozart's compositions, according to the Tomatis method, on sleep quality and behavioral disorders, including auto-/hetero-aggression, irritability, and hyperactivity, in a group of children and adolescents with drug-resistant epilepsy. The study group was composed of 11 outpatients (7 males and 4 females), between 1.5years and 21years of age (mean age: 11.9years), all suffering from drug-resistant epileptic encephalopathy (n=11). All of them had a severe/profound intellectual disability associated with cerebral palsy. During the study period, each patient had to listen to a set of Mozart's compositions 2h per day for fifteen days for a total of 30h, which could be distributed over the day depending on the habits and compliance of each patient. The music was filtered by a device preferably delivering higher sound frequencies (>3000Hz) according to the Tomatis principles. The antiepileptic drug therapy remained unchanged throughout the study period. During the 15-day music therapy, 2 out of 11 ...
Authors: Orpana HM, Lang JJ, Baxi M, Halverson J, Kozloff N, Cahill L, Alam S, Patten S, Morrison H PMID: 29911819 [PubMed - in process]
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