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Mozart's music in children with drug-refractory epileptic encephalopathies

Publication date: September 2015 Source:Epilepsy & Behavior, Volume 50 Author(s): Giangennaro Coppola , Annacarmela Toro , Francesca Felicia Operto , Giuseppe Ferrarioli , Simone Pisano , Andrea Viggiano , Alberto Verrotti Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG discharges and recurrence of clinical seizures in both adults and young patients. In this prospective, open-label study, we evaluated the effect of listening to a set of Mozart's compositions, according to the Tomatis method, on sleep quality and behavioral disorders, including auto-/hetero-aggression, irritability, and hyperactivity, in a group of children and adolescents with drug-resistant epilepsy. The study group was composed of 11 outpatients (7 males and 4 females), between 1.5years and 21years of age (mean age: 11.9years), all suffering from drug-resistant epileptic encephalopathy (n=11). All of them had a severe/profound intellectual disability associated with cerebral palsy. During the study period, each patient had to listen to a set of Mozart's compositions 2h per day for fifteen days for a total of 30h, which could be distributed over the day depending on the habits and compliance of each patient. The music was filtered by a device preferably delivering higher sound frequencies (>3000Hz) according to the Tomatis principles. The antiepileptic drug therapy remained unchanged throughout the study period. During the 15-day music therapy, 2 out of 11 ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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The alacrima, achalasia, and mental retardation syndrome (AAMR) is a newly described autosomal recessive disorder characterized by the onset of these 3 main features at birth or in early infancy. At present, only 16 cases have been reported. Recently, it was shown that AAMR is due to mutations in the guanosine diphosphate (GDP)-mannose pyrophosphorylase A (GMPPA) gene. These mutations induce a significant GDP-mannose overload, which may affect protein glycosylation. Herein, for the first time, we describe 2 adult sisters with AAMR with a previously not reported deleterious homozygous missense mutation c.1118G>C (p.Arg37...
Source: Molecular Syndromology - Category: Molecular Biology Source Type: research
AbstractObjective:To investigate the relationship between obesity and sleep architecture in postmenopausal women.Methods:One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
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Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
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Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Causes of post-stroke epilepsy are manifold and not just restricted to the stroke itself (primary post-stroke epilepsy). These causes range from premorbid conditions already present before the stroke, to morbidity that develops after the stroke, either as a complication of, or independent of, the stroke. Seizures associated with a pre-existing disposition (eg, meningitis, head trauma, or encephalopathy caused by, for example, diabetes or hypertension) can be triggered by stroke or by co-pathologies developing after a stroke (secondary post-stroke epilepsy).
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research
Multiple sclerosis —MS. These two letters can change lives in an instant for young people starting out in their careers and family life. MS is hard to define, hard to treat, and hard to take. Yet over the past two decades, treatment has changed radically, from none to over a dozen disease modifying drugs that can re duce attack rate and mitigate disability. The 2017 revisions of the multiple sclerosis diagnostic criteria1 provide an opportunity for reflection.
Source: Lancet Neurology - Category: Neurology Authors: Tags: In Context Source Type: research
Conclusion: Although the increase of index is not a side effect in all patients, the risk in those who experimented it can determinate an important aggravation of a medic condition. It ´s possible that there´s There may be a contraindication in the use of stabilization splints in patients with sleep respiratory disorders.
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Publication date: February 2018 Source:The Lancet Neurology, Volume 17, Issue 2 Author(s): Josef Finsterer
Source: The Lancet Neurology - Category: Neurology Source Type: research
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Source: The Lancet Neurology - Category: Neurology Source Type: research
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