A System to Build Distributed Multivariate Models and Manage Disparate Data Sharing Policies: Implementation in the Scalable National Network for Effectiveness Research

Conclusion Federated research networks need not limit distributed query functionality to count queries, cohort discovery, or independently estimated analytic models. Multivariate analyses can be efficiently and securely conducted without patient-level data transport, allowing institutions with strict local data storage requirements to participate in sophisticated analyses based on federated research networks.
Source: Journal of the American Medical Informatics Association - Category: Information Technology Authors: Tags: Research and Applications Source Type: research

Related Links:

Alignment of a crystal with the coordinate system of a scanning electron microscope (SEM) is essential for obtaining controlled diffraction conditions or investigating anisotropic material properties. The computer program crystalAligner was developed to enable the weighted constrained alignment of one or two crystal directions in crystals of arbitrary orientation and structure with the coordinate system of a SEM. For a given set of crystal directions, alignment objectives and rotational constraints, the algorithm simulates the rotation of the crystal on any constrained SEM stage and minimizes the misalignment of the crysta...
Source: Journal of Applied Crystallography - Category: Physics Authors: Tags: scanning electron microscopy electron backscatter diffraction optimization computer programs Source Type: research
Multi-wavelength (mw) Bragg coherent X-ray diffraction imaging (BCDI) is demonstrated on a single Au particle. The multi-wavelength Bragg diffraction patterns are inverted using conventional phase-retrieval algorithms where the dilation of the effective pixel size of a pixelated 2D detector caused by the variation of the X-ray beam energy is mitigated by interpolating the raw data. The reconstructed Bragg electron density and phase field are in excellent agreement with the results obtained from conventional rocking scans of the same particle. Voxel sizes of about 63   nm3 are obtained for reconstructions from both approa...
Source: Journal of Applied Crystallography - Category: Physics Authors: Tags: Bragg coherent X-ray diffraction imaging Au nanoparticles energy scanning research papers Source Type: research
Analytical expressions for Gaussian-beam Z-scan and eclipsing Z-scan signals are obtained in a unified format in the case of third-order ...
Source: Journal of the Optical Society of America B - Category: Physics Authors: Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Seyit Ali Güngör, Mehmet Tümer, Muhammet Köse, Sultan ErkanAbstractThe benzaldehyde derivatives (1–6) containing one and/or two propargyl arm(s) attached to the phenolic hydroxyl oxygen atom on the ortho-, meta- or para-positions of the aromatic ring were synthesized and characterized by spectral and microanalytical methods. The molecular structures were of 1, 4–6 determined by the single crystal X-ray crystallography. The benzaldehyde derivatives containing free phenolic groups involved intra- and i...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 26 January 2020Source: Carbohydrate PolymersAuthor(s): Resmi Rajalekshmi, Parvathy Jayasree, John Annie, Joseph RoyAbstractInjectable in situ gelling hydrogels are viable treatment options for meniscal injuries occurring in athletes. The present study aims to develop an injectable hydrogel via borax complexation of oxidized alginate, followed by a self-crosslinking reaction with gelatin through a Schiff’s base reaction. Gelation kinetics and degree of crosslinking could be controlled by changing the concentration of components and the formation of Schiff's base formation was confir...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 26 January 2020Source: Polymer TestingAuthor(s): Kamila Salasinska, Maciej Celiński, Mateusz Barczewski, Michał K. Leszczyński, Monika Borucka, Paweł KozikowskiAbstractThe novel flame retarded unsaturated polyester resins have been developed and prepared by introduction of high nitrogen content additives into the polymer matrix in order to verify their effectiveness in the formation of swollen carbonaceous char inhibiting the burning process of the polymer. The intumescent flame retardants (IFRs) based on mixture or metal complex were developed and characterized by particle size distr...
Source: Polymer Testing - Category: Chemistry Source Type: research
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/C9CP06487G, PaperYuji Isshiki, Shintaro Fujii, Tomoaki Nishino, Manabu Kiguchi A single-molecule junction of 1,4-di(4-pyridyl)benzene (DPB) was prepared in a nano-gap between two Au electrodes using the scanning tunnelling microscopy-based break junction method (STM-BJ). Electric conductance and current versus bias... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Evolved mechanisms of phenotypic plasticity, which are evolutionary processes in their own right, enable species to respond adaptively to their environments. The Scandinavian countries, and Norway in particular, have for many years scored exceptionally hig...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
We report a case of a diagnostic dilemma in a patient with pulmonary melioidosis which radiologically mirrored a bronchogenic carcinoma with mediastinal lymphadenopathy. Such findings were observed in a Computed Tomography (CT) scan (Thorax) and Positron Emission Tomography (PET) scan (Body) in a previously healthy 57-year-old man with no significant medical risk factors for melioidosis other than his previous exposures to soil during outfield military training in Thailand, 37 and 28 years ago. He presented with acute symptoms of dry cough, pleuritic pain and fever. A CT Scan thorax revealed a left lower lobe mass with lef...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ONCOS-102, a promising immunotherapy vaccine, is moving closer to becoming a part of future first-line treatment for mesothelioma. Early clinical trial results announced this week show safety and efficacy when the vaccine is used in combination with standard-of-care chemotherapy for patients with inoperable pleural mesothelioma. Targovax, a Scandinavian pharmaceutical company developing the drug, is moving forward with another study combining ONCOS-102 with a checkpoint inhibitor drug such as Keytruda (pembrolizumab) or Opdivo (nivolumab), along with chemotherapy. “We have seen enough data at this point to be going ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
More News: Information Technology | Legislation | PET Scan | Statistics | Study