The GIF(T) of life: Amazing footage reveals how a human lung is kept alive and BREATHING for a transplant

Surgeons in Phoenix used the Organ Care System to maintain a transplant lung. It is designed to keep organs in a state where they can function outside the body.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractPurpose of ReviewPrimary graft dysfunction is an acute lung injury syndrome occurring immediately following lung transplantation. This review aims to provide an overview of the current understanding of primary graft dysfunction (PGD), including epidemiology, immunology, clinical outcomes, and management.Recent FindingsIdentification of donor and recipient factors allowing accurate prediction of PGD has been actively pursued. Improved understanding of the immunology underlying PGD has spurred interest in identifying relevant biomarkers. Work in PGD prediction, severity stratification, and targeted therapies continue...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
This study provides a therapeutic strategy for targeting asthma inflammation.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 18 October 2018Source: Microvascular ResearchAuthor(s): Reza Rahbarghazi, Rana Keyhanmanesh, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi AhmadiAbstractObjectivesAlthough excitements related to stem cell therapeutic outcomes have been highlighted enormously in asthma, the vast majority of works were conducted by researchers in animal models. Elucidating the mechanisms underlying the therapeutic effects of MSCs in asthmatic rats will provide a rational basis for assuring maximal safety of future clinical application of stem cells. In the current study, we sought to investigate the possibl...
Source: Microvascular Research - Category: Biochemistry Source Type: research
Authors: Liu C, Han M, Zhao L, Zhu M, Xu Q, Song Y, Wang H Abstract OBJECTIVE: This research aimed to explore the significance of low activity of ADAMTS-13 in acute myeloid leukemia (AML) after bone morrow transplantation (BMT), and to evaluate the disease progress and prognosis of the patients with low or normal activity of ADAMTS-13 after BMT. METHODS: 46 AML patients were included in our research. ADAMTS-13 activity was measured before BMT. Their medical indicators were recorded one month after BMT. All the patients were followed up and their disease progression was evaluated afterwards. The medical indicato...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Abstract PURPOSE: Post-operative pulmonary function is an important prognostic factor for lung transplantation. The purpose of this study was to identify factors affecting recovery of forced expiratory volume in 1 second (FEV1) at the first year after lung transplantation. MATERIALS AND METHODS: We retrospectively reviewed the medical records of lung transplantation patients between October 2012 and June 2016. Patients who survived for longer than one year and who underwent pulmonary function test at the first year of lung transplantation were enrolled. Patients were divided into two groups according to wheth...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
ConclusionsLung and liver transplantation in AATD patients are associated with very good long-term survival rates that are comparable to, and sometimes superior to, other transplant indications. Although not currently recommended in AATD, LVRS may have a role in a minority of patients. The value of Alpha 1 Antitrypsin (AAT) augmentation therapy following lung transplantation requires further study. Wherever possible, AAT therapy should be continued in the period around elective surgeries.SummaryAlthough AATD is a widely discussed and researched topic in the literature, surgical intervention for AATD, in addition to the man...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Recipient and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor and recipient age and their interaction and short- and long-term mortality is unknown.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Alpha 1 Antitrypsin Deficiency (AATD) is a genetic cause of emphysema/chronic obstructive pulmonary disease (COPD) and liver disease, making AATD patients a high-risk surgical group. Additionally, patients may eventually require lung and/or liver transplantation or lung volume reduction surgery (LVRS). This narrative review discusses perioperative considerations for elective procedures in AATD patients, and reviews patient outcomes in AATD-related transplantation and LVRS.
Source: American Journal of Surgery - Category: Surgery Authors: Tags: Review Source Type: research
Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the adv...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Case report Source Type: research
AbstractPatients with autoimmune disease –related interstitial lung disease (AID-ILD) occasionally develop radiologic pleuroparenchymal fibroelastosis (PPFE)–like lesions. However, the significance of AID as an etiology of PPFE has not been fully elucidated. The aim of this study is to verify the increase of elastic fibers in AID-ILD p atients and evaluate the prevalence of histological PPFE in patients with AID-ILD. We selected cases of clinically diagnosed AID-ILD and idiopathic pulmonary fibrosis (IPF), in which an autopsy had been performed or in which the patient had undergone pneumonectomy for lung transp...
Source: Virchows Archiv - Category: Pathology Source Type: research
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