ABCG2: The molecular mechanisms of urate secretion and gout.

ABCG2: The molecular mechanisms of urate secretion and gout. Am J Physiol Renal Physiol. 2015 Jul 1;:ajprenal.00242.2015 Authors: Woodward OM Abstract High levels of serum uric acid or urate (SUA) is a human trait that has defied explanation. Is it beneficial? Is it pathogenic? Its role in the human diseases like gout and kidney stones was discovered over a century ago (22, 23) but today emerging new genetic and epidemiological techniques have revived an age old debate over whether high uric acid levels (hyperuricemia) independently increases risk for diseases like hypertension and chronic kidney disease (6-8, 29, 34). Part of the mystery of the role uric acid plays in human health stems from our lack of understanding of how humans regulate uric acid homeostasis, an understanding that could shed light on uric acid's historic role in human adaptation and its present role in human pathogenesis. This review will highlight the recent work to identify the first important human uric acid secretory transporter, ABCG2, and the identification of a common causal ABCG2 variant, Q141K, for hyperuricemia and gout. PMID: 26136557 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research