Cardiovascular diseases in childhood.

[Cardiovascular diseases in childhood]. Radiologe. 2015 Jul 3; Authors: Hart C Abstract Cardiac imaging in childhood poses significant challenges for the instrumentation and the operator. Small cardiac structures, high heart beat rates, non-compliant or sedated patients and in addition to the challenge of detecting acquired heart diseases, a broad spectrum of congenital heart defects (CHD) needs to be addressed, preferably without the burden of ionizing radiation. These challenges require not only accurate anatomical imaging but also a comprehensive assessment of hemodynamic and functional parameters for prognosis and risk stratification. With an incidence of 1 % among all live births, CHDs are the most frequent form of congenital organ dysplasia. Advances in the diagnostics and treatment of even very complex forms of CHD lead to a higher number of patients requiring follow-up with cardiac imaging in childhood. As an example congenital defects, such as tetralogy of Fallot or valvular regurgitation need regular assessment of cardiac volumes and function. Arrhythmogenic right ventricular cardiomyopathy requires recognition of fatty infiltration in the myocardium and in hypertrophic cardiomyopathy or myocarditis evidence of scar tissue or fibrosis portends a poor prognosis for the patient. For adequate assessment of the hemodynamics of complex CHD, the investigator must be aware of the patient's medical history in order to judge the course of the cir...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research

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This commentary refers to ‘Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC)’, by A. Pellicciaet al., 2019;40:19 –33.
Source: European Heart Journal - Category: Cardiology Source Type: research
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Authors: Mavrogeni SI, Tsarouhas K, Spandidos DA, Kanaka-Gantenbein C, Bacopoulou F Abstract Athletic pre-participation screening is essential for minimizing the risk for sudden cardiac death (SCD) in athletes participating in either competitive or leisure sporting activities. The primary causes of SCD in young athletes (
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Cardiovascular causes of sudden unexpected death in children and adolescents (0-17 years) : A nationwide autopsy study in the Netherlands. Neth Heart J. 2018 Sep 03;: Authors: Vos A, van der Wal AC, Teeuw AH, Bras J, Vink A, Nikkels PGJ, Dutch NODO group Abstract BACKGROUND: Little is known about the causes of unexpected death in minors (0-17 years). In young adults an important cause is cardiovascular disease, with primary arrhythmogenic disorders, atherosclerotic events, cardiomyopathies and myocarditis as main contributors. The aim of this autopsy study was to determine the contribut...
Source: Netherlands Heart Journal - Category: Cardiology Authors: Tags: Neth Heart J Source Type: research
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): T.A. Donovan, N. Balakrishnan, I. Carvalho Barbosa, T. McCoy, E.B. Breitschwerdt, P.R. FoxSummaryEndomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp....
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: July 2018 Source:Journal of Comparative Pathology, Volume 162 Author(s): T.A. Donovan, N. Balakrishnan, I. Carvalho Barbosa, T. McCoy, E.B. Breitschwerdt, P.R. Fox Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp. DNA...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
We present a case of athletic heart in an exceptionally physically fit active duty naval aviator who experienced syncope and underwent extensive cardiac testing. He was found to have borderline hypertrophic changes as well as delayed gadolinium enhancement initially concerning for myocarditis. Cardiopulmonary exercise testing revealed an exercise capacity of 120% above the maximum measurable value for his age and gender. He was then diagnosed with athlete's heart and released to active duty with no limitations to his flight status. A challenge is posed to the practicing clinician in differentiating the athletic heart from ...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Checkpoint inhibitors induce a plethora of immune-related adverse events (irAEs) including autoimmune colitis, hepatitis, endocrinopathies, and rarer side effects like neuritis. Here, a case of autoimmune cardiomyopathy (grade 3 CTCAE) and myocarditis under combination therapy with nivolumab plus ipilimumab in a 72-year-old melanoma patient is reported. Treatment induced a partial response for 14 months. However, after 10 infusions the patient developed dyspnea, edema of the legs, ascites and a weight gain of 10 kg because of a decompensated heart insufficiency with a reduced ejection fraction from formerly 48%&ndas...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Brief Communication Source Type: research
Conclusions— CMR identified a likely pathogenesis for sudden cardiac arrest in nearly half of survivors in whom coronary artery disease had been excluded. One in 3 subjects had MACE; risk doubled in those with a CMR diagnosis and some CMR parameters—late gadolinium enhancement, left ventricular ejection fraction, and especially right ventricular ejection fraction—associated with prognosis.
Source: Circulation: Cardiovascular Imaging - Category: Radiology Authors: Tags: Sudden Cardiac Death, Magnetic Resonance Imaging (MRI) Source Type: research
BackgroundAlthough cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. PurposeTo determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. Study TypeSystemic review and meta‐analysis. PopulationPatients with NICM, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), and patients with myocarditi...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Review Article Source Type: research
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