UCLA patient is first to receive successful heart transplant after using experimental 50cc Total Artificial Heart

A petite 44-year-old woman has received a successful heart transplant at Ronald Reagan UCLA Medical Center, thanks to an experimental Total Artificial Heart designed for smaller patients.  The UCLA patient is the first person in California to receive the smaller Total Artificial Heart, and the first patient in the world with the device to be bridged to a successful heart transplant — that is, to go from needing a transplant to receiving one. The 50cc SynCardia temporary Total Artificial Heart is a smaller investigational version of the larger 70cc SynCardia heart, which was approved for use in people awaiting a transplant by the Federal Food and Drug Administration in 2004 and has been used by more than 1,440 patients worldwide. The 50cc device is designed to be used by smaller patients — including most women, some men and many adolescents — with end-stage biventricular heart failure, where both sides of the heart are failing to pump enough blood to sustain the body. The device provides mechanical support until a donor heart can be found.   Nemah Kahala, a wife and mother of five, was transferred to UCLA from Kaiser Permanente Los Angeles Medical Center in March.  She was suffering from restrictive heart muscle disease and in critical condition.  Her heart failure was so advanced that repair surgery and other mechanical assist devices could not help.    Kahala was placed on a life support system called extra corpo...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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β-Adrenergic blockade is an important mechanism for reducing morbidity and mortality in patients with hypertension and heart failure. Esmolol has been used widely for its chronotropic and antihypertensive effects. However, there has been recent inquiry regarding perioperative esmolol use and nociceptive modulation. Conventional postoperative analgesic treatment has relied primarily on opioids, which present their own adverse effects and pharmacoepidemiologic repercussions. Esmolol, to date, has not shown any direct analgesic or anesthetic properties; however, recent studies suggest that esmolol may have antinociceptiv...
Source: Regional Anesthesia and Pain Medicine - Category: Anesthesiology Tags: REGIONAL ANESTHESIA AND ACUTE PAIN: DARING DISCOURSE Source Type: research
Vapotherm last week registered for an initial public offering worth nearly $58 million for the respiratory device it’s developing. Exeter, N.H.-based Vapotherm developed the Precision Flow line of devices to provide high-velocity heated, humidified and oxygenated air to treat patients with conditions such as pneumonia, chronic obstructive pulmonary disease, asthma and heart failure. Some 1,200 of the devices have been sold in the U.S., mostly into hospital ICUs, the company said. In an Oct. 19 filing with the U.S. Securities &Exchange Commission, Vapotherm said the proceeds from the $57.5 million offering ar...
Source: Mass Device - Category: Medical Devices Authors: Tags: Featured Funding Roundup Respiratory Wall Street Beat Vapotherm Source Type: news
Condition:   Heart Failure Intervention:   Device: Cordio Medical Sponsor:   Cordio Medical Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease Intervention:   Drug: macitentan 10 mg Sponsors:   Actelion;   Almac Clinical Technologies, LLC;   Frontier Science&Technology Research Foundation, Inc.;   Covance Central Laboratory Services, LP;   Chiltern International Ltd.;   WorldCare Clinical, LLC;   AcitGraph Corp.;   Medidata Solutions Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study examines the effects of the reform on adverse events, defined as deaths or readmissions occurring within 60 days of hospitalization.Methods: We use Norwegian register data for patients (age 18+) hospitalized between 2009 and 2014 for COPD/asthma (N=25,936), heart failure (N=27,708), hip fracture (N=44,981) and stroke (N=43,313). Our logit models test for conditional effects of the reform, whereby associations between the reform and adverse events vary by whether or not patients were classified as ready for discharge and in need of follow-up care in the community. The models include fixed effects for districts an...
Source: International Journal of Integrated Care - Category: Nursing Source Type: research
Conclusion: The exclusive use of administrative data would have lead our healthcare system down a misleading path of allocating resources to better management and integration of chronic diseases between primary, acute and specialty care.   Instead, by adding social variables as well as patient/provider narratives to our planning, a completely different emphasis resulted: strengthening primary care and enhancing social supports in the community.  Published on 2018-10-23 00:00:00
Source: International Journal of Integrated Care - Category: Nursing Source Type: research
Mesenchymal stem cell therapy for heart failure: a meta-analysis. Herz. 2018 Oct 19;: Authors: Fu H, Chen Q Abstract BACKGROUND: Mesenchymal stem cell (MSC) treatment has emerged as an important adjunct therapy for heart failure. However, the use of MSC to treat heart failure has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of MSC treatment for heart failure. METHODS: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials (RCTs) assessing the influence of MSC treatment on ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
(Natural News) A study found that adding traditional Chinese medicine (TCM) to Western medication can improve the quality of life of patients with chronic heart failure. In China, it is common to administer TCM together with Western medication to treat diseases. Thus, a team of researchers looked whether this was effective in conditions such as...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Neighborhood socioeconomic status (nSES) is associated with cardiovascular morbidity and mortality in the general population; however, its effect on high-risk patients with prevalent coronary artery disease (CAD) is unclear. We hypothesized “double jeopardy,” whereby the association between nSES and adverse outcomes would be greater in high-risk patients with heart failure (HF) and/or prior myocardial infarction (MI) compared to those without. We followed 3,635 individuals (mean age 63.2 years, 42% with HF, 25% with prior MI) with known or suspected CAD over a median of 3.3 years for all-cause death and cardiov...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Due to an increasing prevalence of heart failure but a steady rate of heart transplantation, the number of left ventricular assist devices (LVADs) implanted is growing. These patients present to emergency departments (EDs) with a variety of complications from their implanted device as well as their baseline cardiomyopathy. One-third of patients will present with a dysrhythmia, the most common of which is ventricular tachycardia.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Clinical Communications: Adult Source Type: research
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