UCLA and City of Hope scientists use nanoparticles to shut down mechanism that drives cancer growth

When scientists develop cancer therapies, they target the features that make the disease deadly: tumor growth, metastasis, recurrence and drug resistance. In epithelial cancers — cancers of the breast, ovaries, prostate, skin and bladder, which begin in the organs’ lining — these processes are controlled by a genetic program called epithelial–mesenchymal transition. UCLA Jeffrey Zink Epithelial–mesenchymal transition is regulated by a protein called Twist, which means that Twist directly influences the development of cancer, its spread to other organs and its return after remission. In a major step toward developing a novel therapy that targets epithelial–mesenchymal transition, scientists from UCLA and City of Hope have become the first to inhibit the mechanism of Twist using nanoparticles to deliver a nucleic acid called small interfering RNA, or siRNA, into tumor cells. In mouse models, delivering siRNA into cancer cells inhibited the expression of Twist, which in turn reduced epithelial-mesenchymal transition and dramatically reduced the size of tumors. The study, which was published online in the journal Nanomedicine: Nanotechnology, Biology and Medicine, was led by Jeffrey Zink and Fuyu Tamanoi, both members of the California NanoSystems Institute and Jonsson Comprehensive Cancer Center at UCLA, and Carlotta Glackin of City of Hope Cancer Center. “We were truly surprised by the dramatic effect of delivering Twist siRNA,&r...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In conclusion, these data indicate that KIF23 is a potential therapeutic target for gastric cancer treatment. PMID: 31007778 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: Available online 22 April 2019Source: Life Sciences in Space ResearchAuthor(s): L. Walsh, U. Schneider, A. Fogtman, C. Kausch, S. McKenna-Lawlor, L. Narici, J. Ngo-Anh, G. Reitz, L. Sabatier, G. Santin, L. Sihver, U. Straube, U. Weber, M. DuranteAbstractThe European Space Agency (ESA) is currently expanding its efforts in identifying requirements and promoting research towards optimizing radiation protection of astronauts. Space agencies use common limits for tissue (deterministic) effects on the International Space Station. However, the agencies have in place different career radiation exposure limits (f...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Publication date: Available online 23 April 2019Source: Life SciencesAuthor(s): Muzammal Hussain, Dickson Adah, Muqddas Tariq, Yongzhi Lu, Jiancun Zhang, Jinsong LiuAbstractThe tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer cell biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, the antifungal activity of base analogues, 5-flucytosine (5-FC) and 5-fluorouracil (5-FU), was tested against planktonic cells as well as against mature biofilm.MethodsTests were performed according the EUCAST methodology. Antibiofilm effectiveness of tested drugs was determined by the crystal violet staining method. The cytotoxicity assays was performed according to the ISO 10993-5 norm.Results5-FC and 5-FU were effective against fifteen fluconazole resistant Candida glabrata strains with an average minimal inhibitory concentration (MIC) of 0.152 mg/L and 0.39 mg/L, respectively. Folinic acid (fol...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shengtao Wang, Jingtao Li, Zhou Ye, Jieling Li, Anhe Wang, Jing Hu, Shuo Bai, Jian YinAbstractHerein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes ef...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Srinivasan Ayyanaar, Mookkandi Palsamy Kesavan, Gandhi Sivaraman, Balaji Maddiboyina, Jamespandi Annaraj, Jegathalaprathaban Rajesh, Gurusamy RajagopalAbstractPoly(D, L-lactide-co-glycolic acid) (PLGA) based magnetic microspheres (MMS) hold immense potential for reaching the target of controlled and specific drug delivery site with low toxicity. Herein, we have synthesized the biodegradable PLGA microspheres (MS) containing magnetic iron oxide nanoparticles (MIONPs) by the emulsion solvent evap...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 22 April 2019Source: Chemical Engineering JournalAuthor(s): Yingying Zhang, Lu Zhang, Xiaowen Lin, Lingjie Ke, Bifei Li, Liang Xu, Tingting Lv, Ziying Li, Haijun Chen, Yu GaoAbstractThe clinical outcome of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors is limited by the ambiguous molecular subtypes of non-small cell lung cancer (NSCLC) patients and the emergence of drug-resistance. Here, a nanotheranostic agent ECMI, which is indocyanine green (ICG)-loaded mesoporous silica nanoparticles lidded with ZnO QDs and wrapped with erlotinib-modified chitosan, was developed fo...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8NJ06517A, PaperFaria Sultana, Mohd Aslam Saifi, Sd Riyaz, Geeta Sai Mani, Siddiq Pasha Shaik, Egharevba godshelp osas, Chandraiah Godugu, syeda Shahjahan, Ahmed Kamal Abstract: A series of 2-anilinopyridyl linked benzothiazole-hydrazone conjugates (5a-aa) were designed synthesized and evaluated for their in vitro cytotoxic potency against a panel of cancer cell lines like mouse skin... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Joe Abdo1, Christopher S. Wichman2, Nicholas E. Dietz1,3, Pawel Ciborowski4, John Fleegel1, Sumeet K. Mittal1,5 and Devendra K. Agrawal1* 1Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States 2Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States 3Department of Pathology, CHI Health Creighton University Medical Center, College of Medicine, Omaha, NE, United States 4Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE, United States 5Norton Thoracic Institute, St....
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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