Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet [Biochemical, Molecular, and Genetic Mechanisms]

Conclusions: The high-fat diet induced inflammation in pigs and affected their gene expression of selenoproteins associated with thioredoxin and oxidoreductase systems, local tissue thyroid hormone activity, endoplasmic reticulum protein degradation, and phosphorylation of lipids. This porcine model may be used to study interactive mechanisms between excess fat intake and selenoprotein function.

Source: Journal of Nutrition - July 1, 2015 Category: Nutrition Authors: Zhao, H., Li, K., Tang, J.-Y., Zhou, J.-C., Wang, K.-N., Xia, X.-J., Lei, X. G. Tags: Biochemical, Molecular, and Genetic Mechanisms Source Type: research