Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.

Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.
Hear Res. 2015 Jun 25;
Authors: Kopp-Scheinpflug C, Tempel BL
Abstract
The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).
PMID: 26119177 [PubMed - as supplied by publisher]

Source: Hearing Research - June 25, 2015 Category: Audiology Authors: Kopp-Scheinpflug C, Tempel BL Tags: Hear Res Source Type: research