Immunological Challenges in Vascularised Composite Allotransplantation

Abstract Vascularised composite allotransplantation (VCA) is a new field in transplantation aiming to improve disabled patients’ quality of life. Two tissues appear to play an important role in the immune response: the skin, which is highly immunogenic and the main target of T-lymphocyte-mediated acute rejection, and the vessels, which are targeted by the humoral arm of recipient’s immune response, which lead to chronic rejection, as in solid organ transplantation. In preclinical models, transplantation of bone marrow is associated with mixed chimerism inducing and maintaining tolerance to allogeneic VCA. However, this is not the case clinically. Immunosuppression used in VCA patients is similar to that in solid organ transplantation with similar side effects and complications. However, as a life-enhancing transplant, the careful selection of recipients and a close follow-up cannot be overemphasised.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72Ô...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Clinical trials Methodology/study design, Clinical trials Observational study (Cohort, Case control), Class II, Multiple sclerosis Article Source Type: research
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Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Clinical trials Observational study (Cohort, Case control), Class II, Multiple sclerosis Editorial Source Type: research
CONCLUSIONS: Changes in the self-reported EDSS score in parallel with neurological improvement, were observed in persons with all types of MS after HSCT, employing the "Mexican method". This article is protected by copyright. All rights reserved. PMID: 31394007 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Rattus rattus Source Type: research
AbstractAllogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative treatment for many hematological malignant and non-malignant diseases. A major complication of the procedure is the donor T-cell-mediated graft-versus-host disease (GvHD). GvHD accounts for about 10% of early mortality after transplantation. GVHD is also the major cause of morbidity and disability in the late follow-up phase of transplanted patients, mainly because of the low response to first-line steroids, and the lack of efficient second-line standard treatments. The increasing knowledge regarding GVHD pathogenesis provides new pharmaco...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Trends in Biotechnology - Category: Biotechnology Authors: Tags: Trends Biotechnol Source Type: research
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Source: AGE - Category: Geriatrics Source Type: research
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