Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Conclusion
Post-ischaemic silencing of p66Shc upon reperfusion improves stroke outcome in mice while the expression of p66Shc gene correlates with short-term outcome in patients with ischaemic stroke.

Source: European Heart Journal - July 1, 2015 Category: Cardiology Authors: Spescha, R. D., Klohs, J., Semerano, A., Giacalone, G., Derungs, R. S., Reiner, M. F., Rodriguez Gutierrez, D., Mendez-Carmona, N., Glanzmann, M., Savarese, G., Krankel, N., Akhmedov, A., Keller, S., Mocharla, P., Kaufmann, M. R., Wenger, R. H., Vogel, J. Tags: FASTTRACK BASIC SCIENCE Source Type: research