SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload

Conclusion
Taken together, our data demonstrate, for the first time, that SH2B1 is a key positive mediator of pathological cardiac hypertrophy, and that it primarily acts by regulating JAK2/STAT3 signalling.

Source: Cardiovascular Research - June 30, 2015 Category: Cardiology Authors: Wu, G., Liu, Y., Huang, H., Tang, Y., Liu, W., Mei, Y., Wan, N., Liu, X., Huang, C. Tags: Cardiac biology and remodelling Source Type: research