Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation

Publication date: Available online 30 June 2015 Source:Mutation Research/Genetic Toxicology and Environmental Mutagenesis Author(s): Małgorzata M. Dobrzyńska , Aneta Gajowik , Joanna Radzikowska , Ewa J. Tyrkiel , Ewa A. Jankowska-Steifer We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation. Males were exposed for 8 weeks to BPA, X-rays or both agents, and mated to unexposed females. Pre- and postnatal development of the offspring of exposed males was examined. Both BPA alone and the combined exposure slightly affected postnatal development. Combined exposure induced two-fold higher postnatal mortality than BPA the alone, whereas BPA exposure caused reduced body weight and diminished sperm quality in F1 generation.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research