Ginkgo biloba Extract Inhibits Platelet Activation via Inhibition of Akt

In this study, we found that GBE adenosine diphosphate, collagen, and U4 (U46619) induced platelet aggregation in both platelet-rich plasma and washed platelets. GBE could reduce the adhesion of platelets to a collagen-coated surface and platelet spreading on fibrinogen. The treatment with GBE significantly inhibited the phosphorylation of Akt, suggesting that its inhibition of platelet activation might be mediated by attenuation of the PI3K/Akt pathway.Integr Med Int 2014;1:234-242
Source: Integrative Medicine International - Category: Complementary Medicine Source Type: research