Purple Power For Your Brain

During one of my trips to Brazil a few years ago, I went in search of new healing herbs I could use at my wellness center. That’s when I discovered açaí berries. Now everyone’s talking about these berries. And they really are one of the richest sources in antioxidants, vitamins A, B, C, and E, minerals and omega-3s. In fact, I ended up including powdered açaí berries in one of my supplements. Back then, they were pretty much a novelty outside of South America, but now I even see frozen açaí berry smoothie packs when I’m in the grocery store. And that’s my problem with açaí berries – they grow mostly in the Amazon floodplains, but here in America you can’t get them fresh. Of course, like most fruit and vegetables, freezing them only slightly reduces the nutritional content of the berries. But the process inevitably changes their flavor and texture. And for the best nutritional value and “kick,” it’s impossible to beat any fresh fruit that’s eaten straight from the tree or vine. The locals in the Amazon always eat açaí berries fresh. Then, after a day or so, they just throw them out. I remember eating fresh açaí berries with some of the tribes-people in the Amazon and I felt a noticeable boost – both mentally and physically. These super-berries can enhance your brainpower, something those Big Pharma chemical cr...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Brain Health Nutrition Acai berry anthocyanin extract brain-derived neurotrophic Parkinson’s disease Source Type: news

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In conclusion, CA appears to counteract the neurotoxicity of 6-OHDA by activating PINK1/parkin-mediated mitophagy. PMID: 30707903 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
Aims: Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotective effects of trehalose in the rat model of Parkinson ꞌs disease were the aim of the present study. Main methods: Parkinson's disease model was induced by injecting 6-OHDA in the striatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronal counts were applied to evaluate the neuroprotective effects of trehalose. The autop hagy was studied using the expression of p62 and LC3II/LC3I ratio. In addition, the antioxidant effects of trehalose were assessed by analyzing the levels of nuclear factor (erythro...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
The Parkinson's disease-associated protein kinase PINK1 and ubiquitin ligase Parkin coordinate the ubiquitination of mitochondrial proteins, which marks mitochondria for degradation. Miro1, an atypical GTPase involved in mitochondrial trafficking, is one of the substrates tagged by Parkin after mitochondrial damage. Here, we demonstrate that a small pool of Parkin interacts with Miro1 before mitochondrial damage occurs. This interaction does not require PINK1, does not involve ubiquitination of Miro1 and also does not disturb Miro1 function. However, following mitochondrial damage and PINK1 accumulation, this initial pool ...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Autophagy & Cell Death, Membrane & Intracellular Transport Articles Source Type: research
In conclusion, the present study indicates that DJ-1 knockdown leads to mitochondrial dysfunction in dopaminergic neuron-like cells, at least in part, through suppressing the Akt/GSK3β pathway and impairing the oxidative stress response, as well as through the subsequent increased JNK activation in dopaminergic neuron-like cells. PMID: 30634017 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
ski A Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Neuropharmacol Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30485484 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
Publication date: Available online 17 October 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Zhi Dong Zhou, Ji Chao Tristan Lee, Eng King TanAbstractMutations of F-box only protein 7 (FBXO7) gene are associated with a severe form of autosomal recessive juvenile Parkinson's disease (PD) (PARK15) with clinical features of Parkinsonian-Pyramidal syndrome (PPS). FBXO7 is an adaptor protein in SCFFBXO7 ubiquitin E3 ligase complex that recognizes and mediates degradative or non-degradative ubiquitination of substrates. The FBXO7 protein can regulate cell cycle, proliferation, mitochondrial and proteasome fu...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research
Authors: Ohnishi T, Ohnishi ST, Salerno JC Abstract NADH-quinone oxidoreductase (complex I) is the largest and most complicated enzyme complex of the mitochondrial respiratory chain. It is the entry site into the respiratory chain for most of the reducing equivalents generated during metabolism, coupling electron transfer from NADH to quinone to proton translocation, which in turn drives ATP synthesis. Dysfunction of complex I is associated with neurodegenerative diseases such as Parkinson's and Alzheimer's, and it is proposed to be involved in aging. Complex I has one non-covalently bound FMN, eight to 10 iron-sul...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Abstract A number of independent studies have shown the contribution of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the pathogenesis of several neurodegenerative disorders. Indeed, GAPDH aggregates have been found in many post-mortem samples of brains of patients diagnosed with Alzheimer's and Parkinson disease. Currently, it is accepted that GAPDH-mediated cell death pathways in the neurodegenerative processes are associated with apoptosis caused by GAPDH nuclear translocation and excessive aggregation under oxidative stress conditions. Also the role of GAPDH in neurodegenerative diseases is linked to it ...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway. Toxicology. 2018 Sep 08;: Authors: Yang JM, Huang HM, Cheng JJ, Huang CL, Lee YC, Chiou CT, Huang HT, Huang NK, Yang YC Abstract Paraquat (PQ) as an herbicide has been demonstrated to impair dopaminergic (DAergic) neurons and highly correlate with the etiology of Parkinson's disease (PD). WNT/β-CATENIN signaling is known for the specification and neurogenesis of midbrain DAergic neurons and implicated as a therapeutic target in treating many disease...
Source: Toxicology - Category: Toxicology Authors: Tags: Toxicology Source Type: research
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