Purple Power For Your Brain

During one of my trips to Brazil a few years ago, I went in search of new healing herbs I could use at my wellness center. That’s when I discovered açaí berries. Now everyone’s talking about these berries. And they really are one of the richest sources in antioxidants, vitamins A, B, C, and E, minerals and omega-3s. In fact, I ended up including powdered açaí berries in one of my supplements. Back then, they were pretty much a novelty outside of South America, but now I even see frozen açaí berry smoothie packs when I’m in the grocery store. And that’s my problem with açaí berries – they grow mostly in the Amazon floodplains, but here in America you can’t get them fresh. Of course, like most fruit and vegetables, freezing them only slightly reduces the nutritional content of the berries. But the process inevitably changes their flavor and texture. And for the best nutritional value and “kick,” it’s impossible to beat any fresh fruit that’s eaten straight from the tree or vine. The locals in the Amazon always eat açaí berries fresh. Then, after a day or so, they just throw them out. I remember eating fresh açaí berries with some of the tribes-people in the Amazon and I felt a noticeable boost – both mentally and physically. These super-berries can enhance your brainpower, something those Big Pharma chemical cr...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Brain Health Nutrition Acai berry anthocyanin extract brain-derived neurotrophic Parkinson’s disease Source Type: news

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Abstract Neuroinflammation plays an active role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed that glia maturation factor (GMF), a proinflammatory mediator; is up-regulated in the brain in neurodegenerative diseases and that deficiency of GMF showed decreased production of IL-1β and improved behavioral abnormalities in mouse model of PD. However, the mechanisms linking GMF and dopaminergic neuronal death have not been completely explored. In the present study, we have investigated the expression of NLRP3 inflammasome ...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
Abstract A key feature of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders including Alzheimer disease (AD), Parkinson disease (PD) and Huntington's disease (HD) is abnormal aggregation and deposition of misfolded proteins. Previous studies have shown that autophagy plays an important role in the clearance of disease-linked protein aggregates. In the current study, we report that ibudilast, which is a non-selective inhibitor of phosphodiesterases (PDEs) and an anti-inflammation drug, can induce autophagy and lysosomal biogenesis through mammalian target of rapamycin complex 1 - transcripti...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
This study was designed to investigate the relationship between olfactory bulb and inflammatory pathological alterations and the potential mechanisms. Here we found that rotenone led to typical parkinsonian symptoms and decreased tyrosine hydroxylase (TH)-positive neurons in the olfactory bulb. Additionally, increased NF-κB nuclear translocation and NLRP3 inflammasome components expressions caused by rotenone injection were observed accompanied by the activation of microglia and astrocytes in the olfactory bulb. Rotenone also triggered Drp1-mediated mitochondrial fission and this in turn caused mitochondrial damage. ...
Source: Toxicology Letters - Category: Toxicology Authors: Tags: Toxicol Lett Source Type: research
Abstract The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously present with evident structural derangement and aberrant function under exposure to different stimuli, which might accelerate the corruption of cells. Therefore, the quality control of multiple organelles is of gr...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Parkinson's disease results from the death of dopaminergic neurons in the substantia nigra pars compacta region of the brain. The mechanism of neuron death still remains elusive. Here, we investigated the regulation of a pro ‐apoptotic protein, PUMA by transcription factor, FoxO3a in a model of PD. In healthy cells, transcription factor FoxO3a is localized in cytosol as an inactive complex bound with 14‐3‐3 protein. 6‐OHDA, a Parkinson's disease mimetic, treatment leads to a number of post‐translational modifi cations of FoxO3a which in turn causes its nuclear translocation. In nucleus, FoxO3a in association with...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
We examined changes in peripheral innate immune-related markers in PD cases (n=41) stratified according to risk of developing early dementia. 'Higher Risk'(HR) (n=23) and 'Lower Risk' (LR) (n=18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls. Monocyte subsets and expression of key surface markers were measured using flow cytometry. Serum markers including alpha-synuclein, inflammasome-related caspase-1 and bacterial translocation-related endotoxin were measured using quantitative immuno-based assays. Specific markers were fu...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC. Cell Mol Life Sci. 2019 Nov 23;: Authors: Rovini A, Gurnev PA, Beilina A, Queralt-Martín M, Rosencrans W, Cookson MR, Bezrukov SM, Rostovtseva TK Abstract An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson's disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial outer membrane and targets respiratory complexes lead...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
α-Synuclein penetrates mucin hydrogels despite its mucoadhesive properties. Biomacromolecules. 2019 Nov 13;: Authors: Marczynski M, Rickert CA, Semerdzhiev SA, van Dijk WR, Segers-Nolten IMJ, Claessens MMAE, Lieleg O Abstract Recent research indicates that the progression of Parkinson's disease can start from neurons of the enteric nervous system, which are in close contact with the gastrointestinal epithelium: α synuclein molecules can be transferred from these epithelial cells in a prion-like fashion to enteric neurons. Thin mucus layers constitute a defense line against the exposure of ...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
In this study, it was found that acetaldehyde treatment induced excessive mitochondrial fragmentation, impaired mitochondrial function and caused cytotoxicity in cortical neurons and SH-SY5Y cells. Further analyses showed that acetaldehyde induced the phosphorylation of mitochondrial fission related protein dynamin-related protein 1 (Drp1) at Ser616 and promoted its translocation to mitochondria. The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pre...
Source: Redox Biology - Category: Biology Source Type: research
Abstract Microglia activation is closely linked to ischemia, various chronic neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis), and many other central nervous system diseases. Accumulating evidence suggests that depressing the microglial inflammatory response could be an effective treatment for inflammatory disorders. The integrin αvβ3 inhibitor LXW7 has a neuroprotective effect; however, its anti-inflammatory effects and underlying mechanism remain unclear. Thus, we examined whether LXW7 would inhibit inflammatory cytokines an...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
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