Molecular Analysis of HLA Genes in Romanian Patients with Chronic Hepatitis B Virus Infection

This study's main findings include the identification of certain HLA alleles, such as DQB1*06:03:01, DRB1*13:01:01, DQB1*06:02:01, DQA1*01:03:01, DRB5*01:01:01, and DRB1*15:01:01, which exhibit a significant protective effect against HBV. Additionally, the amino acid residue alanine at DQB1_38 is associated with a protective role, while valine presence may signal an increased risk of hepatitis B. The present findings are important in addressing the urgent need for improved methods of diagnosing and managing CHB, particularly when considering the disease's presence in diverse population groups and geographical regions.PMID:38392185 | PMC:PMC10887826 | DOI:10.3390/cimb46020067
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research