Delivering drugs to the right place

For the 12 million people worldwide who suffer from polycystic kidney disease (PKD), an inherited disorder with no known cure, a new treatment option may be on the horizon. A targeted drug delivery method has been developed that could potentially slow the progression of polycystic kidney disease.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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S Pandita, D Khullar, R Saxena, IC VermaIndian Journal of Nephrology 2018 28(6):482-484 Autosomal dominant polycystic kidney disease is characterized by multiple cysts in both kidneys manifesting in adult life. In general, the disorder is caused by a pathogenic variant in one allele of PKD1 or PKD2 genes, while the other allele is normal. Pathogenic variants in both the alleles are rare and have variable phenotypes, from lethal or perinatal presentation to a mild form in later adulthood, depending on the type of variant. Here, we describe a proband with two variants (p.Thr1773Ile and p.Ala1871Thr in trans) in PKD1 gene, w...
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionsDialysis patients tend to have aortic calcification and a primary tear in the aortic arch. Outcomes are acceptable.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: GoPro® camera proved to be a very interesting tool to document surgerie s without interfering with the procedure and with great educational potential. More studies should be conducted to evaluate the role of this equipment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Condition:   ADPKD Interventions:   Drug: Metformin;   Drug: Tolvaptan Sponsor:   Azienda Ospedaliero-Universitaria Consorziale Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Hepatomegaly was strongly associated with both death and longer hospital stay due to cyst infection.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
A 60-year-old multi-morbid male patient with polycystic kidney disease and secondary chronic renal insufficiency stage G5 A3 according to Kidney Disease: Improving Global Outcomes (KDIGO) classification was referred to our hospital with radiological differential diagnoses of sarcoidosis, ectasia of the pulmonary arteries, lymphoma, or central bronchial carcinoma with contralateral hilar lymph node metastases. He had concomitant arterial hypertension, manifest osteoporosis due to renal osteopathy, secondary compensated renal hyperparathyroidism, compensated metabolic renal acidosis, and diabetes mellitus type 2.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Image Source Type: research
We examined whether hypothalamic paraventricular nucleus (PVN) activation or circulating vasopressin contribute to hypertension and baroreflex dysfunction in the Lewis polycystic kidney (LPK) rat. Results: Bilateral PVN inhibition with muscimol reduced SBP further in urethane-anaesthetized adult LPK rats than in control Lewis rats (−43 ± 4 vs. −18 ± 3 mmHg; P 
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
CONCLUSIONS: Rigorous clinical observation recognises processes ignored by the medical literature, and the correct application of the scientific method helps identify and reveal new nosological entities, confirming with this story's example that, in medicine, there are no exhausted issues. PMID: 30518488 [PubMed - in process]
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Tags: Actas Urol Esp Source Type: research
Conclusion: ADPKD patients with AMI suffer from more severe conditions and difficult therapies, resulting in a poorer prognosis.Kidney Blood Press Res 2018;43:1806 –1812
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
PMID: 30484349 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
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