Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

Conclusions: Our findings provide evidence for early childhood lead exposure resulting in sex-dependent and gene-specific DNA methylation differences in the DMRs of PEG3, IGF2/H19 and PLAGL1/HYMAI in adulthood.

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Citation: Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408577.
Received: 18 April 2014
Accepted: 24 June 2015
Advance Publication: 26 June 2015
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Source: EHP Research - June 26, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research