Is It Bedtime for Benzos?

“Bernard also laughed; after two grams of soma the joke seemed, for some reason, good. Laughed and then, almost immediately, dropped off to sleep.” — Aldous Huxley, Brave New World It’s been a tough few years for benzodiazepines, the pharmaceutical industry’s top-selling family of prescription drugs. Tough in every way, that is, except sales: Xanax remains the world’s most popular pill, and U.S. prescriptions for it and other benzos grow by 12 percent every year. It’s their reputation, long enjoyed, as harmless and effective medicines that’s taking a flurry of hits — some glancing, others on the nose. For starters, researchers have recently posited a link between benzos and Alzheimer’s; they’ve documented an explosion in overdoses and ER visits by people mixing benzos and prescription opiates; and they’ve mapped out the disturbing brain-science of benzo dependency, addiction and withdrawal. Among the many discoveries to result from this mapping is proof that benzos induce reward prediction activity in the brain and increase dopamine release. Just like heroin and cocaine. And yet, many patients continue to be told by their doctors that these meds have little to no downside. They're told that benzos simply offer immediate peace of mind and easy, restful sleep. In a narrow sense, this is correct: Benzos are unrivaled in lightening acute anxiety and putting insomniacs to bed. They can and ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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ConclusionNo significant difference was found in the clinical manifestations, mortality, and complication between children and adults but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - Category: Biology Source Type: research
In this study, we aimed to evaluate the relationships between MMP20 gene polymorphisms and the risk of alcohol-induced ONFH in Chinese Han males. MATERIAL AND METHODS In this case-control study, genotypes of 14 selected SNPs in the MMP20 gene were assayed using MassARRAY in 299 male cases with alcohol-induced ONFH and in 197 healthy males. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the influence of gene polymorphism on occurrence of alcohol-induced ONFH by allelic model analysis, genotype model analysis and haplotype analysis. RESULTS After allelic model analysis, the minimum alleles of ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 22 May 2019Source: Thermochimica ActaAuthor(s): Vitaly Zhelezny, Olga Khliyeva, Igor Motovoy, Nikolay LukianovAbstractAn influence of Al2O3 nanoparticles on the thermodynamic properties of isopropyl alcohol in the liquid phase has been studied. Experimental measurements of the two-phase specific heat capacity have been performed in the temperature range from 184 to 340 K for samples with the mass fractions of the nanoparticles 0.0201, 0.0511 and 0.0996 kg·kg-1. The method of monotonic heating in an adiabatic calorimeter of variable temperature has been applied. The sa...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: 1 July 2019Source: Journal of Photochemistry and Photobiology A: Chemistry, Volume 380Author(s): Anil H. Gore, Akshay S. Patil, Datta B. Gunjal, Vaibhav M. Naik, Ravindra D. Waghmare, Chandrashekhar S. Patil, Govind B. KolekarAbstractHerein we proposed a sustainable solid-state photoluminescent nanofibrous hybrid films fabricated through electrospining of polyvinyl alcohol (PVA) and carbon dots (CDs). The CDs employed during the fabrication hybrid films were derived from waste and abundantly available carbonaceous waste tea residue (WTR) precursor. More interestingly, the photoluminescent PVA/WTR-CDs hybr...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Authors: Roy P, Mukherjee R, Parik M PMID: 31110638 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
We report a case of CH poisoning that manifested with neurotoxicity followed by cardiotoxicity leading to cardiac arrest. With a high index of suspicion and proper management, our patient was discharged with normal neurological outcome. In this case report, we discuss CH poisoning and toxicity with highlights on specific intervention including β-blockers. CH induced arrhythmias have been reported to be refractory to the standard antiarrhythmic medications and respond well to β-blockers. PMID: 31110633 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Conclusions: A total of 6.3% of PCPs working in urban areas in Oman suffered burnout. Long working hours was strongly associated with high occupational burnout. Solutions to eliminate or decrease the rate of burnout involve institutional changes, primarily respecting weekly working hours, and in more severe cases psychotherapy help is very important. PMID: 31110627 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Go online to to view the activity, download slides and practice aids, and complete the post-test to earn credit. This PeerView CME/CNE-certified activity—based on a live event conducted in a MasterClass format held in conjunction with the 2019 meeting of the AACR—discusses how Bruton tyrosine kinase (BTK) inhibitors effectively target aspects of B-cell receptor signaling and covers key evidence and clinical issues related to the use of BTK inhibitors in hematologic malignancies (including agent selection, potential combination regimens, and strategies for overcoming drug intolerance or resis...
Source: Peerview CME/CE Video Podcast - Internal Medicine International - Category: Internal Medicine Authors: Tags: Science, Medicine Source Type: video
ConclusionsThese two observations suggest that voiding cystourethrography (VCUG) should be carefully considered in newborns with severe uropathy, particularly in the case of renal insufficiency. If indicated, thyroid function should be monitored in the following weeks, and in case of hypothyroidism treatment should be started.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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