Possible antiosteoporotic mechanism of Cicer arietinum extract in ovariectomized rats.

CONCLUSION: The ongoing study speculates that the CAE exerts its action through regulation of RANK/RANKL/OPG system. As, CAE not only promotes osteoblast differentiation, but also up-regulates OPG and downregulates RANKL secretion in osteoblasts, subsequently prevents bone loss and osteoporosis. PMID: 26097532 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research

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Publication date: Available online 2 June 2020Source: Journal of Orthopaedic TranslationAuthor(s): Zihao He, Linyang Chu, Xuqiang Liu, Xuequan Han, Kai Zhang, Mengning Yan, Xiaofeng Li, Zhifeng Yu
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Conclusions: Our results provide further evidence to support the important role for the SPON1 gene in the aetiology of PMOP, adding to the current understanding of the susceptibility to osteoporosis. PMID: 32484721 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
(Wiley) A recent study published in the Journal of Bone and Mineral Research found that nitrogen-containing bisphosphonates (N-BPs) such as alendronate, which are widely used to treat postmenopausal osteoporosis, are linked with lower risks of pneumonia and of dying from pneumonia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Osteoporosis is a metabolic bone disorder that leads to low bone mass and microstructural deterioration of bone tissue and increases bone fractures. Resveratrol, a natural polyphenol compound, has pleiotropic ...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ConclusionCurrent guideline-recommended FRAX thresholds without BMD showed low sensitivity. Therefore, 10-year osteoporotic hip fracture probability  ≥ 0.95% and 10-year osteoporotic major fracture probability ≥ 4.95% are recommended as the new thresholds.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Conclusion: PMI is a reliable indicator for determining BMD but is not much influenced by gender variation.
Source: Journal of Forensic Dental Sciences - Category: Dentistry Authors: Source Type: research
BACKGROUND: Osteoporosis is a skeletal disease. It is still not known which of the risk factors have the greatest impact on osteoporosis development. The study aimed to determine how the selected osteoporosis risk factors contribute to the development of t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
(International Osteoporosis Foundation) There is an urgent need for guidance and consensus on the methods for, and reporting of, high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging so that different studies can be compared to each other. This position paper, published by a joint working group from IOF, ASBMR and ECTS addresses the need for standardization of techniques and terminology, provides guidance on interpretation and reporting of results, and discusses unresolved issues in the field.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The objective of this work was to study the risk of pneumonia and pneumonia mortality among patients receiving nitrogen ‐containing bisphosphonates (N‐BPs), non‐N‐BP anti‐osteoporosis medications, and no anti‐osteoporosis medications after hip fracture. We studied a historical cohort using a population‐wide database. Patients with first hip fracture during 2005–2015 were identified and matched by time ‐dependent propensity score. The cohort was followed until December 31, 2016, to capture any pneumonia and pneumonia mortality. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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