Upregulated expression of N-methyl-D-aspartate receptor 1 and nitric oxide synthase during form-deprivation myopia in guinea pigs.

In conclusion, FDM upregulates the expression of NMDAR1 and ncNOS and increases cGMP content in the retina. NMDAR1/NO-cGMP pathway may contribute to abnormal visual signals during myopic progression. PMID: 26097564 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/26097564?dopt=Abstract

Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wen D, Song W, Liu S, Tan X, Liu F Tags: Int J Clin Exp Pathol Source Type: research