National veterans health administration inpatient risk stratification models for hospital-acquired acute kidney injury
Conclusions This study demonstrated that, although all the models tested had good discrimination, performance characteristics varied between methods, and the random forests models did not calibrate as well as the lasso or logistic regression models. In addition, novel modifiable risk factors were explored and found to be significant.
Publication date: Available online 20 January 2020Source: LWTAuthor(s): Derong Lin, Xiaomei Long, Yichen Huang, Yuanmeng Yang, Zhijun Wu, Hong Chen, Qing Zhang, Dingtao Wu, Wen Qin, Zongcai TuAbstractThe effects of mixed fermentation by lactic acid bacteria and Neurospora crassa, and microwave treatment on the composition, structure, and functional properties of okara DF were studied. The results of SEM and EDX showed that the honeycomb structure was more obvious and the content of elemental components was changed after fermentation and microwave treatment. The result of TGA-DSC showed that the thermal stability of the sam...
Publication date: Available online 21 January 2020Source: American Journal of Kidney DiseasesAuthor(s): Dana Miskulin, Daniel E. Weiner, Harold J. Manley
Publication date: Available online 21 January 2020Source: American Journal of Kidney DiseasesAuthor(s): Anne M. Butler, J. Bradley Layton, Vikas R. Dharnidharka, Leah J. McGrath
Publication date: Available online 20 January 2020Source: American Journal of Kidney DiseasesAuthor(s): Yvelynne P. Kelly, Gilad J. Kuperman, David J.R. Steele, Mallika L. Mendu
Around 850 million people currently are affected by different types of kidney disorders.1 Up to 1 in 10 adults worldwide has chronic kidney disease (CKD), which is invariably irreversible and mostly progressive. The global burden of CKD is increasing, and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.2 If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease, CKD progresses to end-stage kidney disease, where life cannot be sustained without dialysis therapy or kidney transplantation.
Much of medical data is buried in the free text of clinical notes and not captured by structured data, such as administrative codes. Natural language processing (NLP) can locate and use information that resides in unstructured free text. Chan et al. demonstrate that NLP is sensitive for identifying symptoms in hemodialysis patients. These findings highlight the benefit NLP may bring to nephrology and should prompt discussion of important considerations for NLP system design and implementation.
Although our Dialysis Outcomes and Practice Patterns Study reported a relatively slow international decrease of hepatitis C virus (HCV) prevalence and incidence in hemodialysis (HD) units from 1996 to 20121 (before the direct-acting antiviral era), Huang et al. now report their direct-acting antiviral–based elimination of HCV from a single HD unit in Taiwan.2 Such eradication of HCV will reduce the clinical burden associated with HCV infection. In addition, HCV eradication should prevent HCV nosocomial transmission.
We read the report by Jadoul et al.1 with great interest in a recent issue in Kidney International. The World Health Organization has set ambitious goals for hepatitis C virus (HCV) eradication using the “micro-elimination” approach.2 Taiwan has one of the highest prevalence and incidence of end-stage kidney disease worldwid e. HCV infection is an important complication among our hemodialysis patients.3 With the advent of the new direct-acting antivirals, complete eradication of HCV infection is one of our key priorities.
A 25-year-old male with end-stage kidney disease from obstructive uropathy and neurogenic bladder presented to the emergency room with generalized tonic-clonic seizures. Two weeks before this presentation, the patient was started on hemodialysis via nontunneled precurved hemodialysis catheter, which was inserted into the right internal jugular vein. A cranial computed tomography obtained for the seizures revealed subcutaneous emphysema of the scalp and air bubbles within the dural venous sinuses (Figure 1a).
AbstractAcute kidney injury (AKI) after hematopoietic stem cell transplantation (HSCT) is associated with high mortality rates. To determine the incidence and risk factors associated with AKI in patients undergoing HSCT during the infusion period, patients admitted for HSCT from 2012 to 2015 were studied. AKI was classified according to the KDIGO (Kidney Disease Improving Global Outcomes) criteria. We analyzed the main comorbidities, underlying conditions, types of transplant, preparative regimens, and use of potentially nephrotoxic drugs as risk factors for AKI. Among the 180 patients (median age 53 years), 69 (36.5...