Viruses, Vol. 16, Pages 274: Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, S & atilde;o Paulo State

Viruses, Vol. 16, Pages 274: Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State Viruses doi: 10.3390/v16020274 Authors: Caio Santos de Souza Giovana Santos Caleiro Ingra Morales Claro Jaqueline Goes de Jesus Thaís Moura Coletti Camila Alves Maia da Silva Ângela Aparecida Costa Marta Inenami Andreia C. Ribeiro Alvina Clara Felix Anderson Vicente de Paula Walter M. Figueiredo Expedito José de Albuquerque Luna Ester C. Sabino Camila M. Romano Dengue virus (DENV) is a prominent arbovirus with global spread, causing approximately 390 million infections each year. In Brazil, yearly epidemics follow a well-documented pattern of serotype replacement every three to four years on average. Araraquara, located in the state of São Paulo, has faced significant impacts from DENV epidemics since the emergence of DENV-1 in 2010. The municipality then transitioned from low to moderate endemicity in less than 10 years. Yet, there remains an insufficient understanding of virus circulation dynamics, particularly concerning DENV-1, in the region, as well as the genetic characteristics of the virus. To address this, we sequenced 37 complete or partial DENV-1 genomes sampled from 2015 to 2022 in Araraquara. Then, using also Brazilian and worldwide DENV-1 sequences we reconstructed the evolutionary history of DENV-1 in Araraquara and estimated the time to the most recent common ancestor (tMR...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research