Viruses, Vol. 16, Pages 275: Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF- & alpha; rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

Viruses, Vol. 16, Pages 275: Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors Viruses doi: 10.3390/v16020275 Authors: César Fernández-de-las-Peñas Gema Díaz-Gil Antonio Gil-Crujera Stella M. Gómez-Sánchez Silvia Ambite-Quesada Juan Torres-Macho Pablo Ryan-Murua Ana I. Franco-Moreno Oscar J. Pellicer-Valero Lars Arendt-Nielsen Rocco Giordano The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whethe...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research