Viruses, Vol. 16, Pages 270: Robust Approaches to the Quantitative Analysis of Genome Formula Variation in Multipartite and Segmented Viruses

We describe the properties of this metric and provide a framework for understanding metric values. Second, we explain how this metric can be applied for different purposes, including testing for genome-formula differences and comparing observations to a reference genome formula value. Third, we re-analyze published data to illustrate the applications and weigh the evidence for previous conclusions. Our re-analysis of published datasets confirms many previous results but also provides evidence that the genome formula can be carried over from the inoculum to the virus population in a host. The simple procedures we propose contribute to the robust and accessible analysis of genome-formula data.
Source: Viruses - Category: Virology Authors: Tags: Technical Note Source Type: research
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