Some ED drugs linked to raised risk of melanoma
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Publication date: Available online 7 April 2020Source: The American Journal of SurgeryAuthor(s): Daniel Cheng, Christopher F. McNicoll, Daniel Kirgan, Maris S. Jones, Mariangela R. Rivera, Gabriela M. Doyle, Margret D. De Guzman, Jennifer Baynosa, St Hill Charles
Authors: La T, Jin L, Liu XY, Song ZH, Farrelly M, Feng YC, Yan XG, Zhang YY, Thorne RF, Zhang XD, Teng L Abstract The deubiquitinase cyclindromatosis (CYLD) functions as a tumour suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although shRNA ...
Conditions: Unresectable Melanoma; Metastatic Melanoma Intervention: Drug: APX005M Sponsor: Apexigen, Inc. Recruiting
Long noncoding RNAs (LncRNAs) lncRNA H19 has been shown to be involved in the chemotherapy resistance of cancer cells. However, the role of lncRNA H19 in chemotherapy resistance of melanoma cells remains unknown. Here, we determined lncRNA H19, miR-18b, and insulin-like growth factor 1 (IGF1) expression by utilizing quantitative real-time PCR. Cell proliferation ability and chemosensitivity were assessed by colony formation assay and MTT assay. Flow cytometry assay was applied to detect cell apoptosis. We discovered that lncRNA H19 was upregulated, but miR-18b was downregulated in melanoma tissues and cisplatin (DDP)-resis...
The objective of this study was to determine whether intensity of tumour-infiltrating lymphocytes (TILs) in a cohort study (N = 4133) is an independent predictor of sentinel lymph node (SLN) status in patients with primary cutaneous melanoma. Of the patients with cutaneous melanoma who resulted negative for nodal metastasis, 50.7% had moderate/marked TILs versus 27.7% among those patients who resulted positive for nod al metastasis. In the multivariate analysis, controlling for sex, age, mitotic rate, ulceration and Breslow, high levels of TILs in primary invasive melanoma was associated with a lower risk of ...
Publication date: Available online 6 April 2020Source: Research in Veterinary ScienceAuthor(s): Emerson Soares Veloso, Ivy Nayra Nascimento Gonçalves, Tatiany Luiza Silveira, Juliane Taynar Espirito Santo, Larissa Vieira Figueiredo, Mary Suzan Varaschin, Geovanni Dantas Cassali, Helen Lima Del Puerto, Enio Ferreira
Condition: Melanoma, Uveal Metastatic Intervention: Biological: Vaccination with IKKb matured Dendritic Cells Sponsor: Hasumi International Research Foundation Not yet recruiting
Breslow thickness (BT) is the most important histopathologic factor for primary melanoma staging. Breslow thickness determines the margins for wide local excision, whether sentinel lymph node biopsy should be performed and subsequent melanoma staging and patient management. The correct determination of a 0.8 mm cut-off in melanoma is important for pathologists since discrepancies leading to a change in stage can have significant clinical implications, including incorrect/inappropriate prognostic information, investigation, management and follow-up.
Current risk stratification methods for primary cutaneous melanoma are based on clinicopathologic variables and are limited in their ability to identify patients at risk of metastasis (Morton et al., 2014). It has previously been shown that other ways of characterizing melanoma such as using the tumor cell adhesion marker integrin β3 through immunohistochemistry (IHC) (Hieken et al., 1996) or quantitative reverse transcription polymerase chain reaction (qRT-PCR) (Meves et al., 2015) are useful in discriminating between primary cutaneous melanomas that had or had not metastasized, for example, to sentinel lymph nodes (SLN).