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UCLA's first lung transplant patient marks 25th anniversary of landmark surgery

Twenty-five years ago, an Orange County woman received the first lung transplant ever performed at UCLA Medical Center.  Today, she is still going strong and dotes on her five grandchildren.  As a result of primary pulmonary hypertension, Julie Hancock, then 26 years old, received a single lung transplant at UCLA on June 12, 1990. Since then, UCLA has performed 887 lung transplants. And UCLA has become one of the largest lung transplant centers in the world with some of the best outcomes.             Courtesy of Julie Hancock Dan and Julie Hancock “What I remember was not being afraid at all but having complete trust in the doctors,” recalled Hancock, whose surgeon was Dr. Hillel Laks. He still operates at UCLA. “I knew the risks, but did not allow myself to think of them. I only thought positively and prayed. I just wanted my life to get ‘off hold’ and get back to some kind of normal.” Hancock remembers that she had “a few dry runs with lungs that ended up being unacceptable even after I was getting prepped for surgery.” The lung she eventually received served her well for more than 14 years until she needed to be re-transplanted because she developed bronchiolitis obliterans.  On Nov. 9, 2004, Hancock underwent a double lung transplant at UCLA with Dr. Abbas Ardehali. This surgery took place just 10 days before her 41st birthday. Now 51, the married mother of two grown kids...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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 >>>Available Here with Free Look Inside Option Correct answer: 3. Both 1 and 2 In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead. In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Conclusion: All patients presented with respiratory symptoms. The hyperlucent zones were only on the left lung, with bronchiectasis and obstructive ventilatory defect in the 3 cases. Two patients reported respiratory infections in childhood. All these features have been described in the literature.Although there are no recommendations regarding the follow-up of this entity, since some severe complications have been reported (eg pulmonary hypertension) monitoring may be necessary.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Conclusion: Post infectious obliterative bronchiolitis is the most common cause of PH in the Indian population.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
Semin Respir Crit Care Med 2017; 38: 701-710 DOI: 10.1055/s-0037-1606223Despite an expanded armamentarium of medical therapies, pulmonary arterial hypertension (PAH) remains a progressive disease associated with significant morbidity and premature mortality. Lung transplantation (LT) is the last safety net for patients failing medical therapy, providing excellent overall long-term survival and health-related quality-of-life outcomes in line with more common parenchymal lung disease indications. Waitlist mortality remains disproportionally elevated, however, reflecting an inability of the lung allocation score to completely...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
Metastatic disease may affect the thorax in a number of different ways, most commonly in the form of lung nodules, lymph node enlargement, pleural effusion, and osseous lesions. Much less commonly, extrathoracic malignancies may embolize to the lungs. Large vessel tumor emboli may be detected in thoracic imaging studies as pulmonary arterial filling defects or as “beaded”-appearing pulmonary vessels. Occasionally, tumor embolization may affect only the small pulmonary arteries and may induce fibrocellular intimal hyperplasia and produce thrombotic vascular occlusion, resulting in increased pulmonary vascular re...
Source: Clinical Pulmonary Medicine - Category: Respiratory Medicine Tags: Images in Pulmonary Medicine Source Type: research
OBJECTIVES In Sweden, two centres perform lung transplantation for a population of about 9 million and the entire population is covered for lung transplantation by government health insurance. Lund University Hospital is one of these centres. This retrospective report reviews the 25-year experience of the Skåne University Hospital Lung Transplant Program with particular emphasis on short-term outcome and long-term survival but also between different subgroups of patients and types of transplant [single-lung transplantation (SLTx) versus double-lung transplantation (DLTx)] procedure performed. METHODS Between January...
Source: Interactive CardioVascular and Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Trachea and bronchi Thoracic Source Type: research
In 9–20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy. Corticosteroid therapy is the mainstay of ILD treatment ...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease European Respiratory Update Source Type: research
avies, S Jodele &C E Dandoy
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
ABSTRACT Lungs are allocated to adult and adolescent transplant candidates (aged ⩾ 12 years) on the basis of age, geography, blood type compatibility, and the lung allocation score (LAS), which reflects risk of waitlist mortality and probability of posttransplant survival. In 2013, the most adult candidates, 2394, of any year were added to the list. Overall median waiting time for candidates listed in 2013 was 4.0 months. The preferred procedure remained bilateral lung transplant, representing approximately 70% of lung transplants in 2013. Measures of short‐term and longterm survival have plateaued since the implementa...
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Lung Source Type: research
Bronchiolitis obliterans (BO) and pulmonary hypertension (PH) are rare and fatal complications of stem cell transplantation (SCT). BO is a non-reversible obstructive lung disease in which bronchioles are compressed and narrowed by fibrosis and/or inflammation. PH arises from increased pulmonary vascular resistance leading to increased right ventricular pressure, right heart failure, and death. PH has not been described in patients with BO after SCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Pediatric Disorders Source Type: research
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