UCLA's first lung transplant patient marks 25th anniversary of landmark surgery

Twenty-five years ago, an Orange County woman received the first lung transplant ever performed at UCLA Medical Center.  Today, she is still going strong and dotes on her five grandchildren.  As a result of primary pulmonary hypertension, Julie Hancock, then 26 years old, received a single lung transplant at UCLA on June 12, 1990. Since then, UCLA has performed 887 lung transplants. And UCLA has become one of the largest lung transplant centers in the world with some of the best outcomes.             Courtesy of Julie Hancock Dan and Julie Hancock “What I remember was not being afraid at all but having complete trust in the doctors,” recalled Hancock, whose surgeon was Dr. Hillel Laks. He still operates at UCLA. “I knew the risks, but did not allow myself to think of them. I only thought positively and prayed. I just wanted my life to get ‘off hold’ and get back to some kind of normal.” Hancock remembers that she had “a few dry runs with lungs that ended up being unacceptable even after I was getting prepped for surgery.” The lung she eventually received served her well for more than 14 years until she needed to be re-transplanted because she developed bronchiolitis obliterans.  On Nov. 9, 2004, Hancock underwent a double lung transplant at UCLA with Dr. Abbas Ardehali. This surgery took place just 10 days before her 41st birthday. Now 51, the married mother of two grown kids...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Conclusion: LCI can be successfully measured in LTx patients, and changes with BOS grade. Longitudinal assessments will reveal whether abnormal LCI in those with preserved FEV1 predicts future clinical change.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
ács A, Czebe K, Csiszér E, Mihály S, Kovács L, Müller V, Elek J, Rényi-Vámos F, Lang G Abstract The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Until August, 2018, 55 lung transplantations were performed in Hungary. This was a retrospective analysis. All patients were listed according to the recommendation of the Lung Transplantation Committee. All implanted lungs have ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
Pulmonary compromise has been shown to significantly contribute to nonrelapse mortality after hematopoietic stem cell transplantation (HSCT) [1-4]. The etiology of these pulmonary complications includes intrapulmonary causes of fibrosis and toxicities from treatment regimens or infections (ie, restrictive lung disease), graft-versus-host disease (GVHD) or bronchiolitis obliterans syndrome (BOS) (ie, obstructive lung disease), and vascular abnormalities (eg, pulmonary hypertension), as well as extrapulmonary causes, such as weakness or sclerodermatous GVHD.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Pulmonary compromise has been shown to significantly contribute to non-relapse mortality after hematopoietic stem cell transplantation (or HSCT).1-4 The etiology of these pulmonary complications includes intrapulmonary causes of fibrosis and toxicities from treatment regimens or infections (restrictive lung disease), graft-versus-host disease or bronchiolitis obliterans syndrome (obstructive lung disease), and vascular abnormalities (e.g. pulmonary hypertension), as well as extrapulmonary causes such as weakness or sclerodermatous GVHD.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
 >>>Available Here with Free Look Inside Option Correct answer: 3. Both 1 and 2 In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead. In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Semin Respir Crit Care Med 2017; 38: 701-710 DOI: 10.1055/s-0037-1606223Despite an expanded armamentarium of medical therapies, pulmonary arterial hypertension (PAH) remains a progressive disease associated with significant morbidity and premature mortality. Lung transplantation (LT) is the last safety net for patients failing medical therapy, providing excellent overall long-term survival and health-related quality-of-life outcomes in line with more common parenchymal lung disease indications. Waitlist mortality remains disproportionally elevated, however, reflecting an inability of the lung allocation score to completely...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
OBJECTIVES In Sweden, two centres perform lung transplantation for a population of about 9 million and the entire population is covered for lung transplantation by government health insurance. Lund University Hospital is one of these centres. This retrospective report reviews the 25-year experience of the Skåne University Hospital Lung Transplant Program with particular emphasis on short-term outcome and long-term survival but also between different subgroups of patients and types of transplant [single-lung transplantation (SLTx) versus double-lung transplantation (DLTx)] procedure performed. METHODS Between January...
Source: Interactive CardioVascular and Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Trachea and bronchi Thoracic Source Type: research
ABSTRACT Lungs are allocated to adult and adolescent transplant candidates (aged ⩾ 12 years) on the basis of age, geography, blood type compatibility, and the lung allocation score (LAS), which reflects risk of waitlist mortality and probability of posttransplant survival. In 2013, the most adult candidates, 2394, of any year were added to the list. Overall median waiting time for candidates listed in 2013 was 4.0 months. The preferred procedure remained bilateral lung transplant, representing approximately 70% of lung transplants in 2013. Measures of short‐term and longterm survival have plateaued since the implementa...
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Lung Source Type: research
Bronchiolitis obliterans (BO) and pulmonary hypertension (PH) are rare and fatal complications of stem cell transplantation (SCT). BO is a non-reversible obstructive lung disease in which bronchioles are compressed and narrowed by fibrosis and/or inflammation. PH arises from increased pulmonary vascular resistance leading to increased right ventricular pressure, right heart failure, and death. PH has not been described in patients with BO after SCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Pediatric Disorders Source Type: research
The objective of this study was to demonstrate our experience with pediatric lung transplants over a 10-year period in a program initially designed for adults.
Source: Clinics - Category: Journals (General) Source Type: research
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