Drug firm Jubilant Life Sciences gets USFDA nod for generic levofloxacin tablets

The drug is used to treat adults with infections such as pneumonia, bacterial sinusitis, chronic bronchitis, skin and skin structure infections etc.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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AbstractFifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (Streptococcus pneumoniae,Streptococcus pyogenes,Haemophilus influenzae andMoraxella catarrhalis). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of theftsI gene amongH. influenzae isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is pe...
Source: Multidisciplinary Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
CONCLUSIONS: This study suggests that symptoms of upper respiratory infection frequently occur with the presentation of IUVFP. The onset of symptoms tended to occur between December and February. The mechanism of viral-mediated UVFP has not been established. Future studies to explore this pathophysiology are needed. PMID: 30124061 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
Conclusions: Concerning adherence patterns include high antibiotic rates for bronchitis, particularly in adolescents, and underuse of narrow-spectrum penicillins in the 0–4 years group.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
In much of the Northern Hemisphere, December through February is prime time for colds, influenza (flu), and other respiratory illnesses. Don’t let a cold or the flu ruin your holidays! Learn how to protect yourself and your family with these tips from the Food &Drug Administration (FDA): Get vaccinated against flu Wash your hands often Limit exposure to infected people Keep stress in check Eat a balanced diet Get enough sleep Exercise Symptoms Most viral respiratory infections, like a cold, come and go within a few days, with no lasting effects. But some cause serious health problems. In addition, people who us...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Consumer Health Health Professionals K-12 Public Health Source Type: news
Chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis and sinusitis. Asymptomatic C. pneumonia carriage is also relatively common. The association of C. pneumonia infections with the COPD course and acute exacerbations is unclear.The aim of the study was to investigate the association between serological features of C. pneumoniae infection with systemic inflammation and clinical features of COPD.The study included 59 patients with stable COPD (41F, 18M; median age 68.5 years, 49 ex-smokers, 10 active smokers) who had no, or had>2 acute COPD ex...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory Infections Source Type: research
Abstract Biofilms play a central role in the pathobiology of otitis media (OM), bronchitis, sinusitis, conjunctivitis, and pneumonia caused by nontypeable Haemophilus influenzae (NTHI). Our previous studies show that extracellular DNA (eDNA) and DNABII proteins are essential components of biofilms formed by NTHI. The DNABII protein family includes integration host factor (IHF) and the histone‐like protein HU and plays a central role in NTHI biofilm structural integrity. We demonstrated that immunological targeting of these proteins during NTHI‐induced experimental OM in a chinchilla model caused rapid clearance of biof...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Abstract Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications. Since the spectrum of pulmonary complications in PIDs is broad, we divided pu...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
(Nationwide Children's Hospital) The laboratory of Lauren Bakaletz, PhD, director, Center for Microbial Pathogenesis and vice president of basic sciences, The Research Institute at Nationwide Children's, studied the biofilm construction capabilities of nontypeable Haemophilus influenzae (NTHI), a bacterium responsible for sinusitis, pneumonia, exacerbations of cystic fibrosis and COPD, bronchitis and ear infections.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Primary immunodeficiency disorders (PIDs) have been described as diseases caused by one or more defects of the immune system. These patients are more likely to experience recurrent and/or severe infections and have a tendency to develop a wide range of complications. Respiratory diseases are the main and initial manifestation for the majority of PID patients and most common complication in this group of patients. Pulmonary complications present a significant cause of morbidity and also mortality among patients suffering from different forms of PIDs. Early diagnosis and appropriate treatment can prevent or...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
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