Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII

Conclusion Late INa exerts distinct effects on Ca2+ homeostasis in atrial myocardium through activation of CaMKII and PKA. Inhibition of late INa represents a potential approach to attenuate CaMKII activation and decreases SR-Ca2+-leak in atrial rhythm disorders. The interconnection with the cAMP/PKA system further increases the antiarrhythmic potential of late INa inhibition.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Ion channels and arrhythmias Source Type: research