Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII
Conclusion
Late INa exerts distinct effects on Ca2+ homeostasis in atrial myocardium through activation of CaMKII and PKA. Inhibition of late INa represents a potential approach to attenuate CaMKII activation and decreases SR-Ca2+-leak in atrial rhythm disorders. The interconnection with the cAMP/PKA system further increases the antiarrhythmic potential of late INa inhibition.
Source: Cardiovascular Research - Category: Cardiology Authors: Fischer, T. H., Herting, J., Mason, F. E., Hartmann, N., Watanabe, S., Nikolaev, V. O., Sprenger, J. U., Fan, P., Yao, L., Popov, A.-F., Danner, B. C., Schondube, F., Belardinelli, L., Hasenfuss, G., Maier, L. S., Sossalla, S. Tags: Ion channels and arrhythmias Source Type: research