Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load

Conclusion SCR events overcome source–sink mismatch to trigger PVCs at a critical CaSR threshold. Above this threshold, PVCs emerge due to increased probability and reduced variability in timing of SCR events, leading to significant diastolic depolarization. Sites of lower electronic load, such as the PS, are preferential locations for triggering.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Ion channels and arrhythmias Source Type: research