Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation

Conclusion
ISM is a novel VP inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis. It induces a direct GRP78-Src interaction, leading to cytoplasmic Src activation. ISM contributes to pulmonary vascular hyperpermeability of LPS-induced ALI in mice.

Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W.-S. F., Ge, R. Tags: Vascular biology Source Type: research