Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism

Conclusion We identify the specific pathways affected by tyrosine kinase inhibitors in mammalian cardiomyocytes, interactions with biological sex, and a role for oestrogen in modulating drug efflux and metabolism. These findings represent a critical step toward reducing the incidence of cardiotoxicity with tyrosine kinase inhibitor chemotherapeutics.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Cardiac biology and remodelling Source Type: research