Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension

Conclusions
Perlecan HS chains are important for normal vascular arborization and recruitment of pericytes to pulmonary vessels. Perlecan HS deficiency also attenuates hypoxia-induced PH, where the underlying mechanisms involve impaired FGF2/FGFR1 interaction, inhibition of PASMC growth, and altered cell–matrix interactions.

Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Chang, Y.-T., Tseng, C.-N., Tannenberg, P., Eriksson, L., Yuan, K., de Jesus Perez, V. A., Lundberg, J., Lengquist, M., Botusan, I. R., Catrina, S.-B., Tran, P.-K., Hedin, U., Tran-Lundmark, K. Tags: Integrative physiology and pathophysiology Source Type: research