Three-Dimensional Optoacoustic and Laser-Induced Ultrasound Tomography System for Preclinical Research in Mice: Design and Phantom Validation.

Three-Dimensional Optoacoustic and Laser-Induced Ultrasound Tomography System for Preclinical Research in Mice: Design and Phantom Validation. Ultrason Imaging. 2015 Jun 18; Authors: Ermilov SA, Su R, Conjusteau A, Anis F, Nadvoretskiy V, Anastasio MA, Oraevsky AA Abstract In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents. PMID: 26088582 [PubMed - as supplied by publisher]
Source: Ultrasonic Imaging - Category: Radiology Tags: Ultrason Imaging Source Type: research