Bile Acid Determination after Standardized Glucose Load in Pregnant Women

Conclusion There is a difference between fasting and nonfasting total serum bile acids after a 100-g glucose load in healthy pregnant women.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Tags: Case Report Source Type: research

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n C Abstract OBJECTIVE: To evaluate enzymatic total serum bile acid quantification as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated with ursodeoxycholic acid (UDCA). DESIGN: Cohort. SETTING: One UK university hospital. POPULATION: 29 ICP cases treated with UDCA. METHODS: Serial samples were collected prospectively throughout gestation. Total serum bile acids were measured enzymatically and individual bile acids by High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Data were log-transformed and analysed with random effects generalised leas...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.MethodsCoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n = 23) and in those complicated with ICP (n = 13), were investigated.ResultsA significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105 ± 0.010 vs. 0.069 ± 0.011, P 
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Nature Reviews Gastroenterology &Hepatology, Published online: 20 August 2019; doi:10.1038/s41575-019-0201-3PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Amer J Perinatol DOI: 10.1055/s-0039-1694726 Objective To investigate the fetal atrioventricular conduction system in intrahepatic cholestasis of pregnancy (ICP) by measuring the fetal mechanical PR interval and to explore the significance of predicting the severity of the disease. Study Design Forty pregnant women diagnosed with ICP, classified as severe and mild, and 40 healthy pregnant women participated in the study. Fetal mechanical PR interval was calculated, and fetal mechanical PR interval and neonatal outcome were compared between the groups. The relationship between the mechanical PR interval and ...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
The objective of this study was to determine whether ICP is associated with specific long ‐term comorbidity.Material and methodsThe study population comprised 571 women with ICP in at least one pregnancy who were compared with 1333 pregnant women without ICP during 1969 ‐1988 at Tampere University Hospital, Finland. The cohort's follow‐up time was 44 years. All ICD‐10 classification discharge diagnoses were examined for the women in the ICP group from 1998 to 2013 and ICD‐10 diagnoses from outpatient care from 1969 to 2013.ResultsAt least one disease of the digestive system had been diagnosed in 50.4% (288/5...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Ursodeoxycholic acid, the currently recommended treatment for intrahepatic cholestasis of pregnancy (ICP), does not reduce adverse perinatal outcomes and its routine use"should be reconsidered," conclude investigators in the PITCHES randomized controlled trial.Reuters Health Information
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
Abstract Intrahepatic cholestasis of pregnancy (ICP) is a gestation-specific liver disorder, defined most often as the onset of pruritus, usually from the third trimester of pregnancy, associated with abnormal liver test results and/or increased total serum bile acids and spontaneous relief after delivery. The 21-year-old patient was admitted to our ward in the 11th week of pregnancy due to raised liver enzymes. The first onset of pruritus and jaundice appeared a month before hospitalization. Immunology tests and Toxoplasma gondii were negative. We excluded viral etiology, while alpha-1-antitrypsin, serum and urin...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
WEDNESDAY, Aug. 7, 2019 -- For women with intrahepatic cholestasis of pregnancy, treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes, according to a study published online Aug. 1 in The Lancet. Lucy C. Chappell, Ph.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 1 August 2019Source: The LancetAuthor(s): Hanns-Ulrich Marschall
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 1 August 2019Source: The LancetAuthor(s): Lucy C Chappell, Jennifer L Bell, Anne Smith, Louise Linsell, Edmund Juszczak, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton, Irshad Ahmed, Rita Arya, Virginia Beckett, Amarnath Bhide, Heather Brown, George Bugg, Helen Cameron, Nishigandh Deole, Madhuchanda DeySummaryBackgroundIntrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission. Ursodeoxyc...
Source: The Lancet - Category: General Medicine Source Type: research
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