A Community Research Resource of Microbiome-Derived Factors Modulating Host Physiology in Obesity, Digestive and Liver Diseases, and Nutrition (R24)

Funding Opportunity RFA-DK-15-012 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to invite applications from multidisciplinary research teams to create a community research resource of key members of the microbiota and factors they elaborate which modulate host physiology and pathophysiology related to obesity, nutrition, or liver, exocrine pancreatic, or digestive diseases, and to disseminate it broadly to the research community, in order to advance the development of microbiome-based interventions for prevention and treatment of these diseases.The resource will include annotated genome sequences and cultures of the key microbes, chemical structures of the key compounds they elaborate, datasets used to identify key microbes and compounds, and software for novel analytic methods developed to enable their identification. .
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Publication date: Available online 25 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Raseen Tariq, Page Axley, Ashwani K. SingalNonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease worldwide with a strong association with metabolic syndrome. NAFLD is truly a systemic disease and is associated with a plethora of extra-hepatic manifestations or comorbidities. These are either related to secondary effects of associated obesity or from pathophysiological effects of insulin resistance in NAFLD. Three most common causes of increased morbidity and mortality associa...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
The objective of the present study was to investigate the association between hair and urine Al levels and obesity.MethodsA total of 206 lean and 205 obese non-occupationally exposed subjects (30-50 y.o.) were enrolled in the study. Hair and urine Al levels were assessed with ICP-MS. Laboratory quality control was performed using the certified reference materials of human hair, plasma, and urine.ResultsHair and urinary Al levels in obese subjects were significantly higher by 31% and 46% compared to the control levels, respectively. The presence of hypertension (41% cases), atherosclerosis (8%), type 2 diabetes melli...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), fibrosis, cirrhosis or Hepatocellular Cancer (HCC). Nevertheless, Cardiovascular Disease (CVD) is the most common cause of morbidity and mortality in NAFLD/NASH patients. Current guidelines suggest the use of p...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Condition:   Nonalcoholic Fatty Liver Disease (NAFLD) Intervention:   Procedure: Bariatric surgery Sponsor:   Taipei Medical University Hospital Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
This article provides a systematic mini-review of the literature concerning traditional Chinese medicine for modulation of the intestinal microbiota to ameliorate obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease in China. Initially, the relationship between traditional Chinese medicine and intestinal microbiota was introduced, followed by specific research results on this relationship based on 25 original articles. Therefore, this mini-review will provide a complementary and integrative approach for the treatment of these obesity-related diseases.
Source: Holistic Nursing Practice - Category: Nursing Tags: FEATURES Source Type: research
Publication date: Available online 14 August 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Fereidoun Azizi, Farzad Hadaegh, Farhad Hosseinpanah, Parvin Mirmiran, Atieh Amouzegar, Hengameh Abdi, Golaleh Asghari, Donna Parizadeh, Seyed Ali Montazeri, Mojtaba Lotfaliany, Farzin Takyar, Davood KhaliliSummaryThe Middle East and north Africa are home to different populations with widely varying cultures, histories, and socioeconomic settings. Hence, their health status, health management, and access to appropriate health care differ accordingly. In this Review, we examine data on the historical and prospective sta...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Liver and gastrointestinal tract II Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Liver and gastrointestinal tract II Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Obesity and the metabolic syndrome Source Type: research
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