Mayo Clinic and United Therapeutics Collaborate on Lung Restoration Center
JACKSONVILLE, Fla., and SILVER SPRING, Md. — Mayo Clinic in Jacksonville, Florida, and United Therapeutics Corporation (NASDAQ: UTHR) today announced a collaboration to build and operate a lung restoration center on the Mayo campus. The goal is to significantly increase the volume of lungs for transplantation by preserving and restoring selected marginal donor lungs, making them [...]
Kevin Budding, Jessica van Setten, Eduard A. van de Graaf, Oliver A. van Rossum, Tineke Kardol-Hoefnagel, Johanna M. Kwakkel-van Erp, Erik-Jan D. Oudijk, C. Erik Hack, Henderikus G. Otten
Despite advances in device technology and treatment strategies infection remains a major cause of adverse events (AE) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013-2015.
Specialized T cells in induced bronchus-associated lymphoid tissue regulate alloimmune responses in the lung allograft.
We read with great interest the review by Yanagawa et al, entitled Surgery for tumors of the heart,1 where the authors thoroughly review cardiac tumors classification, diagnosis sequence as well as the suggested method of treatment for the different kinds of tumors. The authors address sarcoma's as one of the rare malignant tumors and suggest a two-step surgical approach to sarcoma that involve the heart and lung.
Zerina Nelson, four, of Mesa, Arizona, was diagnosed with Hermansky-Pudlak syndrome, a genetic condition characterized by albinism and vision considered legally blind
Conditions: Lung Transplant Rejection; Antibody-mediated Rejection Interventions: Drug: Belatacept; Drug: Carfilzomib Sponsors: Duke University; Bristol-Myers Squibb Not yet recruiting
We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. We discuss the role of nebulized amphotericin B in treating invasive pulmonary fungal disease in children. To our knowledge, this is the first pediatric case of endobronchial fusariosis reported in the literature.
Chronic lung allograft dysfunction or CLAD, encompasses a variety of phenotypes including both obstructive and restrictive phenotypes as detected by pulmonary function testing (PFTs), and has advanced the understanding of current clinical guidelines1-5. From the initial classification of chronic lung allograft rejection based primarily on pulmonary function testing, clinical guidelines now encompass CLAD phenotypes, presumed causes, characteristic imaging findings, and refinement of histopathological grades.
Abstract Ceftolozane-tazobactam (C/T) pharmacokinetics during extracorporeal membrane oxygenation (ECMO) has not been previously studied. In this work we report on the C/T plasmatic levels in a lung transplant (LTX) recipient during ECMO, treated with C/T (i.v., 2 g ceftolozane and 1 g tazobactam, every 8 hours]) for a Pseudomonas aeruginosa pulmonary infection. PMID: 30642936 [PubMed - as supplied by publisher]
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