Adverse drug reactions in hiv/aids patients at a tertiary care hospital penang, malaysia.

ADVERSE DRUG REACTIONS IN HIV/AIDS PATIENTS AT A TERTIARY CARE HOSPITAL PENANG, MALAYSIA. Jpn J Infect Dis. 2015 Jun 12; Authors: Khan K, Khan AH, Sulaiman SA, Soo CT, Akhtar A Abstract Current study is aimed to explore and observe adverse drug reactions occurrence of antiretroviral therapy among HIV/AIDS patients.An observational retrospective study of all patients on HAART therapy diagnosed with HIV infection from Jan 2007 to Dec 2012 was conducted at Hospital Pulau Pinang, Malaysia. Patient socio-demographic details along with clinical features and susceptible ADRs were observed during the study period.Out of 743 patients 571 (76.8%) were male and 172 (23.1%) were female. Overall 314 (42.2%) patients had experienced adverse drug reactions. A total number of 425 (57.2%) adverse drug reactions were reported among which 311 (73.1%) occurred in males and 114 (26.8%) in female patients, with a significant statistical relationship (p=0.02, OR=1.21). Overall 239 (56.2%) ADRs were recorded among Chinese, 94 (22.1%) in Malay, and 71 (16.7%) in Indian, which had a statistical significant association with ADRs (p-value=0.05, OR=1.50). Out of total 425 (57.2%) ADR's, Lipodystrophy was recorded 151 (35.5%) followed by Skin rashes 80 (18.8%), Anaemia 74 (17.4%) and Peripheral Neuropathy 27 (6.3%).The findings of present study suggest that there is a need of intensive monitoring for ADRs in HIV treatment centres of Malaysia. PMID: 260737...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research