Prognostic factors in Crimean-Congo hemorrhagic fever and the effect of leukocyte counts on mortality.

Prognostic factors in Crimean-Congo hemorrhagic fever and the effect of leukocyte counts on mortality. Jpn J Infect Dis. 2015 Jun 12; Authors: Bastug A, Kayaaslan B, Kazancioglu S, Aslaner H, But A, Akinci E, Yetkin MA, Eren S, Bodur H Abstract Crimean-Congo hemorrhagic fever is a life threatening illness. We aimed to detect the effect of the leukocyte counts on survival. This is the first study analyzing the relationship between mortality and leukocyte counts. A total of 220 patients were evaluated retrospectively. The mortality rate was found 16.4%. The analysis of relationship between leukocyte counts and mortality rates showed us some important clues for pathogenesis. ROC curve analysis revealed that if the leukocyte counts on admission were ≥ 2950/mm(3), mortality rate could be predicted with 62.1% sensitivity. In consideration of the mean hospitalization length in fatal cases (4.3 days), third-admission day leukocyte counts were compared. Increase of the neutrophils and decrease of the lymphocytes and monocytes were found as significant risk factors for mortality (p = 0.01, p = 0.037, p = 0.001). The mortality risk was found 8-12 folds higher in patients with upper levels of cut- off for leukocytes (2950 µl), LDH (967 U/L) and aPTT (42.4 s), ALT (>119.5 u /l) which were determined as an independent predictors of mortality. The depletion of monocytes, lymphocytes and the increase of neutrophil counts were correlated with p...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research