Four out of ten Brits may naturally show fewer flu symptoms

ConclusionA study of 1,414 unvaccinated people showed those with T cells targeting virus nucleoprotein still got infected by flu, but had fewer symptoms. The logic is that people with fewer symptoms are less likely to spread the virus through coughs and sneezes, which may slow the spread of both seasonal and pandemic flu strains.This is plausible, but was not directly tested in this study, so we don't know if it's true in real life. The research team suggested vaccines that boost T cell numbers might be worth exploring, as an alternative to those that try to stop virus infection altogether. An added potential benefit of their finding was that lessened symptoms in one virus strain showed similar signs in another. That said, only two virus types were tested, so we don't know whether this "cross-reactivity" is more widespread.The findings suggest around 43% of people had some form of this natural immunity, but it's not clear if this is across a broad range of flu viruses or just a couple.The study is encouraging, but is in its early stages of understanding, raising as many questions as it answers. For example: Is it possible to boost this natural symptom immunity in those that have it? How common is this natural immunity in the public? Is it possible to transfer this symptom immunity to those that don’t have it? How useful is this at preventing new cases of flu or deaths from flu? If you are particularly vulnerable to the effects of a flu infection due to ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Swine flu Source Type: news

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Publication date: Available online 17 November 2018Source: The Annals of Thoracic SurgeryAuthor(s): Masaya Tamura, Isao Matsumoto, Yusuke Tanaka, Daisuke Saito, Shuhei Yoshida, Seiichi Kakegawa, Tomoyasu Kumano, Yosuke Shimizu, Hiroyasu Tamamura, Tsuyoshi Takanaka, Hirofumi TakemuraAbstractBackgroundThe aim of this study was to compare outcomes of primary treatment with stereotactic body radiation therapy (SBRT) versus sublobar resection (SLR) for clinical stage I non-small cell lung cancer (NSCLC) in patients with medical comorbidities.MethodsConsecutive patients who underwent SBRT (n=106) or SLR (wedge resection: n=100 a...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In conclusion, infants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to A. lumbricoides showed no such impairment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
r Lal Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and endocytosis had remained elusive until now. In the present study, we observed co-localization of IAV with a lipid raft marker ganglioside, GM1, on the host surface. Further, we isolated the lipid raft micro-domains from IAV infected cells and detected IAV protein in the raft fraction. Finally, raft disruption using Methyl-β-Cyclodextrin revealed significant r...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to particip...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionsHPV prevalence in the oral mucosa of the assessed FA patients was higher than reported in the general population. Additional studies with collection of sequential samples are needed to know the natural history of the presence of multiple HPV types in these individuals and its association with the development of tumors, to evaluate the implementation of preventive measures, such as vaccination, and to guide early treatment.This article is protected by copyright. All rights reserved.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: Original Report Source Type: research
ConclusionsWe report a case of a 67-year-old man with hypothalamic hypopituitarism secondary to a suprasellar metastasis from a primary small cell lung cancer, and we review ten cases of hypothalamic hypopituitarism due to metastases, including our patient. Recognizing hypopituitarism can be challenging, especially in the elderly, whose symptoms such as lethargy and visual decline may be mistaken for the natural aging process. In patients with established metastatic conditions, the symptoms may be wrongly attributed to malignancy or to the side effects of therapy. When a patient is suspected of having hypopituitarism, a ho...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 16 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donatella Feretti, Roberta Pedrazzani, Elisabetta Ceretti, Mario Dal Grande, Ilaria Zerbini, Gaia Claudia Viviana Viola, Umberto Gelatti, Francesco Donato, Claudia ZaniAbstractAir pollution has well-known harmful effects on human beings, causing both acute and chronic diseases. Some data suggest that genetic damage occurring early in life may influence the risk of having cancer and other chronic diseases in adulthood. Therefore, there is a growing interest in studying the genotoxic activit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
ConclusionRadium-223 is a valuable therapeutic alternative in the treatment of patients with mCRPC in early stages of the disease, with a good safety profile. Its benefits extend to the bone environment.ResumenContextoEliminar las metástasis óseas, restaurar/preservar la morfología ósea y prevenir/retrasar los eventos óseos constituyen un objetivo fundamental en el manejo del cáncer de próstata resistente a la castración metastásico (CPRCm). Radio-223 es la primera terapia alfa-dirigida con acción sobre el hueso que aumenta la supervivencia en estos paci...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Publication date: December 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 6Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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