Four out of ten Brits may naturally show fewer flu symptoms

ConclusionA study of 1,414 unvaccinated people showed those with T cells targeting virus nucleoprotein still got infected by flu, but had fewer symptoms. The logic is that people with fewer symptoms are less likely to spread the virus through coughs and sneezes, which may slow the spread of both seasonal and pandemic flu strains.This is plausible, but was not directly tested in this study, so we don't know if it's true in real life. The research team suggested vaccines that boost T cell numbers might be worth exploring, as an alternative to those that try to stop virus infection altogether. An added potential benefit of their finding was that lessened symptoms in one virus strain showed similar signs in another. That said, only two virus types were tested, so we don't know whether this "cross-reactivity" is more widespread.The findings suggest around 43% of people had some form of this natural immunity, but it's not clear if this is across a broad range of flu viruses or just a couple.The study is encouraging, but is in its early stages of understanding, raising as many questions as it answers. For example: Is it possible to boost this natural symptom immunity in those that have it? How common is this natural immunity in the public? Is it possible to transfer this symptom immunity to those that don’t have it? How useful is this at preventing new cases of flu or deaths from flu? If you are particularly vulnerable to the effects of a flu infection due to ...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Swine flu Source Type: news

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Publication date: February 2019Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 55Author(s):
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
ConclusionsWe found the precise anatomy of the connective tissue layer from umbilical artery to urinary bladder and the superior vesical artery. Our procedure based on the precise anatomy obtained in this study is reasonable anatomically as a method for separation of the vesicouterine ligament during radical hysterectomy.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study investigated the modulation of micro-RNAs associated with the PI3K/AKT/mTOR-axis by mango polyphenols (MP) in MCF-12A non-cancer and MDA-MB231 breast cancer cell lines. MP reduced proliferation in the cancer cells by up to 90% (10 mg GAE/L) but did not cause cytotoxicity in the non-cancer cells within the same concentration range. In contrast, in TNF-α-treated non-cancer MCF-12A cells, MP significantly decreased expression and phosphorylation of NF-κB while modulating mRNA and protein levels of PI3K/AKT/mTOR and up-regulated miR-126. The mechanistic involvement of miR-126 was investigated using its...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
In this study, Se-enriched peanut protein nanoparticles-stabilized Pickering emulsions (PPEs) were used to encapsulate 5DN to enhance its bioaccessibility, cellular uptake and transport rate. The preparation of PPEs, and their digestion profiles in gastrointestinal tract, cell uptake and transport were investigated. Results showed that the bioaccessibility of 5DN was significantly higher within PPEs (18.3%) than in bulk oil (9.2%). Besides, PPEs-encapsulated 5DN has a greater apical-to-basolateral (AP-BL) transport rate (26.9 × 10−6 cm s−1) than 5DN (21.7 × 10−6 cm s−1). ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Chia-Yuan Chang, Bing-Ying Ho, Tzu-Ming PanAbstractColorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. Chemotherapy is the usual treatment, but entails side effects. Although lactic acid bacteria (LAB) ameliorate CRC, the effects of LAB-fermented skim milk are unknown. Thus, we investigated the effect of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU 101FM) in combination with chemotherapy on CRC, and its effect on chemotherapeutic side effects in vivo. NTU 101FM + chemotherapy treatm...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
ConclusionsTiming for oral rehabilitation may differ depending on the treatment modality followed for mandibular tumors in the patient with oral cancer. However, most patients in this cohort underwent rehabilitation with removable mandibular resection prostheses regardless of the timing of care. Endosseous implants were used infrequently, but research is needed to better understand their potential role and indication in the patient with oral cancer.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Here ’s what most medical experts agree on: People 50 and older should be screened for colon cancer. Here’s what is more controversial: Whether that screening should start, routinely, at age 45. Recently, the American Cancer Society (ACS) recommended that colon cancer screenings start at age 45. The ir recommendation was based in large part on an uptick […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Authors: Kaufman MB Abstract Arikayce (amikacin liposome inhalation suspension) for Mycobacterium avium complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. PMID: 30766008 [PubMed]
Source: P and T - Category: Drugs & Pharmacology Tags: P T Source Type: research
Abstract Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing attention is human bocavirus 1 (HBoV1). Notably, HBoV1 capsids can cross-package recombinant (r)AAV2 genomes, yielding rAAV2/HBoV1 chimeras that specifically transduce polarized human airway epithelia (pHAEs). Here, we largely expanded the repertoire of rAAV/BoV chimeras, by assembling packaging plasmids encoding the capsid genes of four additional primate bocaviruses, HBoV2...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Mol Ther Methods Clin Dev Source Type: research
Publication date: Available online 16 February 2019Source: Veterinary ParasitologyAuthor(s): Rama Jayaraj, Chellan Kumarasamy, Luke Norbury, David Piedrafita, Peter SmookerAbstractThe immunogenicity and efficacy of Fasciola DNA vaccines have not yet been comprehensively summarised in the form of a systematic review and meta-analysis. Though multiple vaccine studies with respect to Fasciola vaccines exist, the variance in the experimental parameters has made comparison difficult.We conducted a bibliographic database search in Scopus, PubMed, Science Direct, Cochrane Library, EMBASE and Web of Science databases, limited to p...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
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