Recent Progress on Natural α-glucosidase Inhibitors Derived from the Plants and Microorganisms

Curr Med Chem. 2023 Nov 27. doi: 10.2174/0109298673272908231115101520. Online ahead of print.ABSTRACTα-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase inhibitors are mostly discovered from plants and microorganisms, the recent advance in natural αglucosidase inhibitors over the past five years has been reviewed in this article, and 139 distinct α-glucosidase inhibitors from the plants and microorganisms were classified into ten groups based on their chemical structures, including flavonoids (34), xanthones (6), alkaloids (8), benzopyrones / benzofuranones (8), terpenes (23), saponins (8), phenols / alcohols (25), esters (18), chalcone (5) and other compounds (4). In this review, we mainly focused on the novel chemical structures and the various biological activities of theses natural AGIs. Some of the selected natural compounds exhibit powerful α-glucosidase inhibitory activity and anti-tumor activity, may hold promise to become the candidate drugs for treating type II diabetes and cancer in future.PMID:38013439 | DOI:10.2174/0109298673272908231115101520
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research