Up-regulation by overexpression of c-MET in fibroblastic foci of usual interstitial pneumonia

CONCLUSION: Upregulation of c-MET in FF of ILD with UIP pattern further confirms the key role of the proto-oncogene c-MET in its pathogenesis, possibly representing an interesting and easily-detectable molecular target for selective therapy using specific inhibitors in future clinical trials, similar to lung cancer. It is reasonable to speculate that molecular alterations in FF can also be detected in FF by transbronchial cryobiopsy.PMID:37812383 | DOI:10.32074/1591-951X-920
Source: Pathologica - Category: Pathology Authors: Source Type: research