Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population

This study aimed to investigate the relationship between serum osteocalcin level and carotid intima-media thickness (C-IMT) in a metabolically healthy population. Methods: A total of 476 subjects with normal values for weight, glucose tolerance, blood pressure, and lipids (age range, 20–75 years; 155 men, 201 premenopausal women, 120 postmenopausal women) from the Shanghai Obesity Study were recruited for this cross-sectional study. Subjects with a history of cardiovascular disease or carotid plaque were excluded. C-IMT was measured by ultrasonography. Serum osteocalcin level was assessed by an electrochemiluminescence immunoassay. Results: Median C-IMT in the entire study population was 0.55 mm with an interquartile range of 0.50–0.60 mm. C-IMT in premenopausal women was significantly lower than that in men and postmenopausal women (all P 
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research