Hydronephrosis alters cardiac ACE2 and Mas receptor expression in mice

Conclusions:
Hydronephrosis increased cardiac ACE and suppressed ACE2 and Mas receptor levels. AT1 blockade caused sustained activation of cardiac ACE2 and Mas receptor, but ACE inhibitor had the limitation of such activation of Mas receptor in hydronephrotic animals.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - June 12, 2015 Category: Biomedical Science Authors: Zhang, Y., Ma, L., Wu, J., Chen, T. Tags: Original Articles Source Type: research