Correspondence Livebirth after uterus transplantation

Mats Brännström and colleagues1 reported the first livebirth after uterus transplantation. The pregnancy was complicated by pre-eclampsia, resulting in preterm delivery. Immunosuppression, aged uterus, and assisted reproduction—individually or together—might explain development of pre-eclampsia. The patient had congenital absence of uterus and vagina associated with unilateral renal agenesis. Presence of only one kidney is thought to be a possible risk factor for pre-eclampsia in kidney donors. Gestational hypertension or pre-eclampsia are more likely to be diagnosed in kidney donors than in healthy non-donors.
Source: LANCET - Category: Journals (General) Authors: Tags: Correspondence Source Type: research

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Authors: special issue: “Focus on pediatric nephrology”, Bruni V, Petrisano M, Tarsitano F, Falvo F, Parisi F, Cucinotta U, Betta P, Di Benedetto V, Scuderi MG, Pensabene L, Sestito S, Cuppari C, Fede C, Chimenz R, Concolino D Abstract Alport's syndrome (AS, OMIM 301050) is a hereditary disorder characterized by progressive renal failure, hearing impairment and ocular changes. It is clinically and genetically heterogeneous and in its natural history, renal disease progresses from microscopic haematuria to proteinuria, and finally to progressive renal insufficiency. AS is caused by an inherited defect in...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Colavita L, Salpietro C, Cuppari C, Sallemi A, Di Benedetto V, Concolino D, Marseglia L, D'Angelo G, Gitto E, Betta P, Fede C, Conti G, Chimenz R Abstract Nephrotic Syndrome (NS) is a rare diseases (around 2-7 cases per 100.000 children per year) characterized by proteinuria ≥50 mg/kg/day (or ≥40 mg/m2/h) or a proteinuria/creatininuria ratio>2 (mg/mg); hypoalbuminaemia less than 25 g/l and edema. The protein leakage, with the consequent hypoalbunaemia and edema, due to podocyte alterations may be caused by genetic diseases, immunological ...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Chimenz R, Sallemi A, Fusco M, Cannavò L, Salvo V, Marseglia L, Cucinotta U, Gitto E, Concolino D, Arrigo T, Salpietro C Abstract The natural history of children with end stage renal disease is dialysis until a transplant can be done. There are two types of dialysis: hemodialysis and peritoneal dialysis (1). Peritoneal dialysis is preferred in young children because getting the vascular access for hemodialysis is challenging (2). Catheters should be surgically placed in a paramedian or lateral abdominal region with an extremity located in D...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
In humans, oxidative stress is involved in the development of diabetes, cancer, hypertension, Alzheimers' disease, and heart failure. One of the mechanisms in the cellular defence against oxidative stress is the activation of the Nrf2-antioxidant response element (ARE) signalling pathway. Computation of activity, efficacy, and potency score of ARE signalling pathway and to propose a multi-level prediction scheme for the same is the main aim of the study as it contributes in a big amount to the improvement of oxidative stress in humans. Applying the process of knowledge discovery from data, required knowledge is gathered an...
Source: IET Systems Biology - Category: Biology Source Type: research
The transcription factor B cell CLL/lymphoma 11B (BCL11B) is indispensable for T lineage development of lymphoid progenitors. Here, we show that chimeric antigen receptor (CAR) expression during early phases of ex vivo generation of lymphoid progenitors suppressed BCL11B, leading to suppression of T cell–associated gene expression and acquisition of NK cell–like properties. Upon adoptive transfer into hematopoietic stem cell transplant recipients, CAR-expressing lymphoid progenitors differentiated into CAR-induced killer (CARiK) cells that mediated potent antigen-directed antileukemic activity even across MHC b...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil. Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, andmaternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum. Results A total of 22 women had at least 1 pregnancy during the considered timeinterval, and 3 of them had> 1 pregnancy, totalizing 25 pregn...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls.MethodsFifty ‐nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery s ystem. Adverse pregnancy outcomes were defined as preterm delivery (delivery 3 days, infant death/transfer to acute facility and low birth weight (
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
AbstractPurpose of ReviewTo review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients.Recent FindingsThere is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk. There is no observed increase in fetal complications or eclampsia post-kidney donation. Preeclampsia is more commonly observed in ki...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
ABSTRACT Background: Liver transplantation (LT) is a successful treatment for both acute liver failure and end‐stage liver disease. The number of women of reproductive age undergoing LT is increasing. Pregnancy outcomes are favourable but there is still a lack of prognostic markers. We aimed to identify factors predictive of adverse pregnancy outcomes in LT recipients. Methods: An analysis of all pregnancies occurring in LT recipients from 1989‐2016 at King's College Hospital was performed. Clinical data of 162 conceptions in 93 women was reviewed. Descriptive and regression analyses were done to examine associations b...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
In this study, we found a low rate of preeclampsia in a low-to-moderate risk cohort, with an incidence of AKI and maternal mortality consistent with reported literature. PMID: 28352008 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
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