Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources.
Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources. Infect Genet Evol. 2015 Jun 4; Authors: Lee JH, Pascua PN, Decano AG, Kim SM, Park SJ, Kwon HI, Kim EH, Kim YI, Kim H, Kim SY, Song MS, Jang HK, Park BK, Choi YK Abstract In 2011-2012, contemporary North American-like H3N2 swine influenza viruses (SIVs) possessing the 2009 pandemic H1N1 matrix gene (H3N2pM-like virus) were detected in domestic pigs of South Korea where H1N2 SIV strains are endemic. More recently, we isolated novel reassortant H1N2 SIVs bearing the Eurasian avian-like swine H1-like hemagglutinin and Korean swine H1N2-like neuraminidase in the internal gene backbone of the H3N2pM-like virus. In the present study, we clearly provide evidence on the genetic origins of the novel H1N2 SIVs virus through genetic and phylogenetic analyses. In vitro studies demonstrated that, in comparison with a pre-existing 2012 Korean H1N2 SIV [A/swine/Korea/CY03-11/2012 (CY03-11/2012)], the 2013 novel reassortant H1N2 isolate [A/swine/Korea/CY0423/2013 (CY0423-12/2013)] replicated more efficiently in differentiated primary human bronchial epithelial cells. The CY0423-12/2013 virus induced higher viral titers than the CY03-11/2012 virus in the lungs and nasal turbinates of infected mice and nasal wash samples of ferrets. Moreover, the 2013 H1N2 reassortant, but not the intact 2012 H1N2 virus, was transmissible to n...
[The Conversation Africa] Despite the availability of vaccines for influenza - or flu - the virus continues to kill people across the world. According to the World Health Organisation, flu epidemics result in 3 million to 5 million cases of severe illness and about 290 000 to 650 000 deaths each year.
This study provides initial evidence for the utility of this novel, brief intervention as an adjunct to standard adherence counselling, for improving adherence to ART.
Authors: Pérez-García F PMID: 31326095 [PubMed - as supplied by publisher]
We report this case to highlight the possibility of afebrile dengue in endemic areas. PMID: 31324095 [PubMed - in process]
[Nation] The Ministry of Health has declared Kenya free of the avian and swine flu following a scare of an outbreak of the deadly diseases over the weekend.
From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Click arrow to play Download TWiV 557 (41 MB .mp3, 67 min) Subscribe (free): iTunes, Google […]
(University of Tennessee at Knoxville) On average, American colleges and universities with nursing programs offer about one hour of instruction in handling catastrophic situations such as nuclear events, pandemics, or water contamination crises, according to two recent studies coauthored by a nursing professor at the University of Tennessee, Knoxville.
ConclusionDifferences were noted between parasite species found in Mediterranean Europe and northern Europe, where a range of zoonotic parasites were endemic alongside sanitation-related parasites. We suggest that the scarcity of zoonotic parasites in southern Europe in the medieval period may reflect contrasts in climate between northern and southern Europe.SignificanceThe repeated identification of roundworm eggs suggests that al-Andalus was less hygienic than historically depicted. We did not note a difference between parasites found in Muslim and Christian regions of Iberia, and the predominance of parasites spread by ...
This study was designed to determine the in-vitro antibacterial and ex-vivo immunomodulatory efficacy of garlic (Allium sativum) and ginger (Zingiber officinale) extracts post dietary supplementation for 900-one-day-old Sasso broiler chicks. The in-vivo protective action of these extracts against avian pathogenic MDR Escherichia coli (E. coli) O78 challenge was evaluated after 21 days of extracts supplementation. Garlic extract exhibited broader antimicrobial spectra against MDR E. coli O78 and S. aureus isolates. Through the 21 days of garlic or ginger dietary supplementation, the chicks’ innate immune response was ...