Breast cancer 'tumour trigger' that spreads disease discovered

ConclusionAn Edinburgh-based team used mice engineered to develop breast cancer to better understand how it spreads from breast tissue to the lung, where it can be fatal. They identified specific chemical signals and receptors on immune cells called macrophages that were involved in the spread. By genetically tampering with one of the signalling pathways, they were able to reduce some of the cancer spread, raising hopes that this might be a future treatment avenue.Fiddling with the genetics in the same way as was done for the mice would probably not be a viable treatment for humans. Aside from ethical and technical issues, genetic manipulation of this nature could lead to a range of side effects. However, there are potentially other ways of blocking the same signalling pathway.The results were encouraging, but they are at a very early research stage. Right now, we don’t know if this would work in humans, because it has only been tested in mice. While biologically similar, mice and humans do differ in potentially important ways. The only way to know if disrupting this signalling pathway might be useful in minimising breast cancer spread to the lungs would be to do experiments on humans. We also don’t know if this treatment helped the mice live longer, experience less pain or respond better to other treatments. Similarly, the genetic manipulation didn’t stop the cancer spreading completely to the lungs, it just reduced it. Hence, we are a long way off stopping...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news

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ConclusionsWhile QoL in disease-free breast cancer survivors 5  years post-diagnosis was largely comparable to the general population on average, still many survivors suffered from adverse effects. There appears to be a need for ongoing screening and support regarding fatigue, sleep problems, cognitive problems, arthralgia/pain, menopausal/sexual symptoms, phy sical performance, and weight problems during and several years following breast cancer therapy.
Source: Quality of Life Research - Category: Health Management Source Type: research
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research
ConclusionsOverall, women with MBC receiving first-line endocrine therapy have a good QOL. The addition of palbociclib to letrozole maintains health-related QOL and improves pain scores in treatment-na ïve postmenopausal patients with ER+/HER2− MBC compared with letrozole alone. Significantly greater delay in deterioration of health-related QOL was observed in patients without progression versus those who progressed and in patients with an objective response versus non-responders.ClinicalTrials .gov: NCT01740427 (https://clinicaltrials.gov/ct2/show/NCT01740427)
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
This study assessed the effects of a cardiac rehabilitation program on cardiorespiratory fitness, quality of life, and depressive symptoms in breast cancer survivors. METHODS: Charts were reviewed to evaluate the cardiac rehabilitation model. The program consisted of 1 weekly supervised session for 22 group sessions. Each patient was provided with personalized aerobic and resistance exercises plus 12 group educational sessions to encourage behavioral adoption to a healthy lifestyle. Cardiorespiratory fitness (direct VO2peak), quality of life (Short Form-36 Health Status [SF-36] and Functional Assessment of Cancer Ther...
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - Category: Rehabilitation Authors: Tags: J Cardiopulm Rehabil Prev Source Type: research
Conclusions Five years after surgery, the patients showed regular func tionality levels on the ipsilateral upper limb and decreased quality of life, especially in the group manifesting pain.Resumo Objetivo Avaliar se h á correlação entre a funcionalidade e a qualidade de vida em pacientes com sobrevida de cinco anos submetidas ao tratamento cirúrgico para câncer de mama e, secundariamente, avaliar a função do membro superior homolateral à cirurgia, e a qualidade de vida em função do tipo de cirurgia mamá ria e da presença de dor. Méto...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
ConclusionsVLNT continues to demonstrate its value as a safe and effective treatment option for lymphedema after breast cancer therapy. Significant reductions in volume are accompanied by a decrease in symptoms and improvement in quality of life.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Digestive troubles, pain, skin irritation and arm swelling among possible problems
Source: Cancercompass News: Breast Cancer - Category: Cancer & Oncology Source Type: news
Digestive troubles, pain, skin irritation and arm swelling among possible problems
Source: WebMD Health - Category: Consumer Health News Source Type: news
Digestive troubles, pain, skin irritation and arm swelling among possible problemsSource: HealthDay Related MedlinePlus Page: Breast Cancer
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
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